Sofya S. Starnovskaya, Liliana E. Nesterenko, Roman S. Popov, Natalya N. Kirichuk, Viktoria E. Chausova, Ekaterina A. Chingizova, Artur R. Chingizov, Marina P. Isaeva, Ekaterina A. Yurchenko, Anton N. Yurchenko
{"title":"Paragliomastix luzulae（原名 Acremonium striatisporum）KMM 4401 及其与西班牙青霉 KMM 4689 的共培养物的代谢物图谱","authors":"Sofya S. Starnovskaya, Liliana E. Nesterenko, Roman S. Popov, Natalya N. Kirichuk, Viktoria E. Chausova, Ekaterina A. Chingizova, Artur R. Chingizov, Marina P. Isaeva, Ekaterina A. Yurchenko, Anton N. Yurchenko","doi":"10.1007/s13659-024-00459-7","DOIUrl":null,"url":null,"abstract":"<div><p>The marine holothurian-derived fungal strain KMM 4401 has been identified as <i>Paragliomastix luzulae</i> using 28S rDNA, ITS regions and the partial <i>TEF1</i> gene sequences. The metabolite profile of the fungal culture was studied by UPLC-MS technique. The strain KMM 4401 is a source of various virescenoside-type isopimarane glycosides suggested as chemotaxonomic feature for this fungal species. Also <i>Px. luzulae</i> KMM 4401 was proposed as possible source of new bioactive secondary metabolites especially antimicrobials. Moreover, the co-cultures of <i>Px. luzulae</i> KMM 4401 with another marine fungus <i>Penicillium hispanicum</i> KMM 4689 inoculated simultaneously or after two weeks were investigated by same way. It was shown, that <i>P. hispanicum</i> KMM 4689 suppressed the production of most of <i>Px. luzulae</i> KMM 4401 metabolites. On the other hand, the co-cultivation of <i>P. hispanicum</i> KMM 4689 and <i>Px. luzulae</i> KMM 4401 resulted in increasing of production of main deoxyisoaustamide alkaloids of <i>P. hispanicum</i> KMM 4689 on 50–190%.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8000,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00459-7.pdf","citationCount":"0","resultStr":"{\"title\":\"Metabolite profiles of Paragliomastix luzulae (formerly named as Acremonium striatisporum) KMM 4401 and its co-cultures with Penicillium hispanicum KMM 4689\",\"authors\":\"Sofya S. Starnovskaya, Liliana E. Nesterenko, Roman S. Popov, Natalya N. Kirichuk, Viktoria E. Chausova, Ekaterina A. Chingizova, Artur R. Chingizov, Marina P. Isaeva, Ekaterina A. Yurchenko, Anton N. Yurchenko\",\"doi\":\"10.1007/s13659-024-00459-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The marine holothurian-derived fungal strain KMM 4401 has been identified as <i>Paragliomastix luzulae</i> using 28S rDNA, ITS regions and the partial <i>TEF1</i> gene sequences. The metabolite profile of the fungal culture was studied by UPLC-MS technique. The strain KMM 4401 is a source of various virescenoside-type isopimarane glycosides suggested as chemotaxonomic feature for this fungal species. Also <i>Px. luzulae</i> KMM 4401 was proposed as possible source of new bioactive secondary metabolites especially antimicrobials. Moreover, the co-cultures of <i>Px. luzulae</i> KMM 4401 with another marine fungus <i>Penicillium hispanicum</i> KMM 4689 inoculated simultaneously or after two weeks were investigated by same way. It was shown, that <i>P. hispanicum</i> KMM 4689 suppressed the production of most of <i>Px. luzulae</i> KMM 4401 metabolites. On the other hand, the co-cultivation of <i>P. hispanicum</i> KMM 4689 and <i>Px. luzulae</i> KMM 4401 resulted in increasing of production of main deoxyisoaustamide alkaloids of <i>P. hispanicum</i> KMM 4689 on 50–190%.</p><h3>Graphical Abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":718,\"journal\":{\"name\":\"Natural Products and Bioprospecting\",\"volume\":\"14 1\",\"pages\":\"\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2024-06-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s13659-024-00459-7.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Products and Bioprospecting\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s13659-024-00459-7\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Products and Bioprospecting","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s13659-024-00459-7","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Metabolite profiles of Paragliomastix luzulae (formerly named as Acremonium striatisporum) KMM 4401 and its co-cultures with Penicillium hispanicum KMM 4689
The marine holothurian-derived fungal strain KMM 4401 has been identified as Paragliomastix luzulae using 28S rDNA, ITS regions and the partial TEF1 gene sequences. The metabolite profile of the fungal culture was studied by UPLC-MS technique. The strain KMM 4401 is a source of various virescenoside-type isopimarane glycosides suggested as chemotaxonomic feature for this fungal species. Also Px. luzulae KMM 4401 was proposed as possible source of new bioactive secondary metabolites especially antimicrobials. Moreover, the co-cultures of Px. luzulae KMM 4401 with another marine fungus Penicillium hispanicum KMM 4689 inoculated simultaneously or after two weeks were investigated by same way. It was shown, that P. hispanicum KMM 4689 suppressed the production of most of Px. luzulae KMM 4401 metabolites. On the other hand, the co-cultivation of P. hispanicum KMM 4689 and Px. luzulae KMM 4401 resulted in increasing of production of main deoxyisoaustamide alkaloids of P. hispanicum KMM 4689 on 50–190%.
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Natural Products and Bioprospecting serves as an international forum for essential research on natural products and focuses on, but is not limited to, the following aspects:
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