加巴喷丁治疗自闭症谱系障碍合并智力障碍患者的挑战行为：病例报告

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-06-18 DOI:10.1108/amhid-06-2023-0021

Stefano Marini, Lucia D'Agostino, Carla Ciamarra, Domenico De Berardis, Alessandro Gentile

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引用次数: 0

摘要

目的本病例报告旨在介绍使用加巴喷丁治疗自闭症谱系障碍和合并智力障碍患者问题行为的临床经验。自闭症谱系障碍是一种神经发育障碍，智障的发病率很高。自闭症谱系障碍患者的挑战行为非常普遍。近年来，自闭症症状源于γ-氨基丁酸抑制性神经递质缺乏的假说越来越受到重视。设计/方法学/方法探讨一名患有自闭症谱系障碍和严重智障的成年男子服用加巴喷丁后行为症状的改善。原创性/价值目前，尚无授权药物用于治疗自闭症谱系障碍的症状特征，但有药物用于治疗合并精神病理学方面的症状。作者希望推测加巴喷丁在重塑自闭症患者体内α-2-δ亚单位的表达和神经信息处理方面的假设功能。

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Gabapentin treatment for challenging behaviors in autism spectrum disorder and coexisting intellectual disability: a case report

Purpose The purpose of this case report is to report the clinical experience of the use of gabapentin in the management of problem behaviors in a person with autism spectrum disorder and comorbid intellectual disability. Autism spectrum disorder is a neurodevelopmental disorder with a high prevalence of intellectual disability. Challenging behaviors in autism spectrum disorder are very common. In recent years, the hypothesis that the symptoms of autism derive from a deficiency of the inhibitory neurotransmission of gamma-aminobutyric acid is gaining considerable weight. Design/methodology/approach Exploring behavioral symptoms improvement in an adult man with ASD and severe intellectual disability taking gabapentin. Findings The rating scales used show improvement in challenging behaviors and aggressions. No side effects were observed. Originality/value Currently, there are no authorized drugs for the treatment of the symptomatic features of autism spectrum disorder, but drugs are used for comorbid psychopathological aspects. The authors want to speculate on a hypothetical function of gabapentin in remodeling the expression of alpha-2-delta subunits in people with autism and the processing of neural information.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.