钯催化咔唑与炔基溴化物的直接炔基化反应

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2024-10-21 DOI:10.1002/ejoc.202400649

Jyothis Dharaniyedath , Vikash Kumar , Parthasarathy Gandeepan

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引用次数: 0

摘要

咔唑衍生物在药物化学和材料化学中至关重要，但获得多样化的取代仍然具有挑战性。在这里，我们介绍了一种通过钯催化 C-H 活化咔唑的 C1 和 C8 烷炔化的区域选择性方法。该方法提供了获得单炔基化和二炔基化衍生物的直接途径，解决了炔基化咔唑基材料稀缺的问题。我们的研究拓宽了咔唑官能化的合成工具箱，为光电子学、生物成像等领域提供了潜在应用，同时有助于开发可持续的 C-H 活化方法。

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Palladium‐Catalyzed Direct Alkynylation of Carbazoles with Alkynyl Bromides

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Palladium‐Catalyzed Direct Alkynylation of Carbazoles with Alkynyl Bromides

Carbazole derivatives are vital in medicinal and materials chemistry, yet accessing diverse substitutions remains challenging. Here, we introduce a regioselective approach for C1 and C8 alkynylation of carbazoles via palladium‐catalyzed C−H activation. This method provides a direct route to mono‐ and di‐alkynylated derivatives, addressing the scarcity of alkynylated carbazole‐based materials. Our study broadens the synthetic toolbox for carbazole functionalization, offering potential applications in optoelectronics, bio‐imaging, and beyond, while contributing to developing sustainable C−H activation methodologies.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.