DNA 编码文库中光诱导的 β- 羟基砜合成

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2024-07-02 DOI:10.1039/d4cc02193b

Lijun Xue , Jiaqing Yu , Ying Zhong , Junyun Chen , Chao Li , Kexin Yang , Nicolas Duchemin , Yun Jin Hu

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引用次数: 0

摘要

我们在此描述了亚砜盐与常见烯烃在可见光下发生光氧化反应，从而在 DNA 上生成 β-羟基砜的过程。该工艺具有广泛的底物兼容性，可实现中等到极好的转化率。最重要的是，它为合成富含 Csp3 的 DNA 编码文库提供了一种直接、高效、无金属的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Light-induced β-hydroxy sulfone synthesis in DNA-encoded libraries†

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Light-induced β-hydroxy sulfone synthesis in DNA-encoded libraries†

We here describe a visible-light photooxidation of sulfinate salts with common alkenes to yield β-hydroxy sulfones on DNA. This process demonstrates a broad substrate compatibility and achieves conversion rates ranging from moderate to excellent. Most importantly, it presents a straightforward, efficient, and metal-free approach for synthesizing Csp³-rich DNA-encoded libraries.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.