通过 N-杂环羰基催化不对称合成 C3 功能化 2,1-苯并噻嗪 2,2-二氧化物

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2024-07-09 DOI:10.1039/d4cc01754d

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引用次数: 0

摘要

我们在此介绍一种利用 N-杂环碳烯（NHC）催化对 2,1-苯并噻嗪 2,2- 二氧杂环进行对映选择性 C3 功能化的方法。我们的方法包括与不同的 N 型和 O 型亲核物进行一系列 [3+3] 环加成和开环反应，然后进行硅烷化。该方法克服了针对 C3 位的选择性难题，具有广泛的底物范围和高对映选择性。这标志着 NHC 催化转化领域的重大进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Enantioselective synthesis of C3-functionalized 2,1-benzothiazine 2,2-dioxides by N-heterocyclic carbene catalysis†

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Enantioselective synthesis of C3-functionalized 2,1-benzothiazine 2,2-dioxides by N-heterocyclic carbene catalysis†

We present herein an approach for the enantioselective C3-functionalization of 2,1-benzothiazine 2,2-dioxides using N-heterocyclic carbene (NHC) catalysis. Our method involves a sequence of [3+3] cycloaddition and ring-opening reactions with different N- and O-nucleophiles, followed by silylation. Overcoming the challenge of selectivity targeting the C3 position, this protocol demonstrates a broad substrate scope and high enantioselectivity. This marks a significant advancement in the field of NHC-catalyzed transformations.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.