{"title":"评估Pistacia atlantica Oleoresin 对 2 型糖尿病患者血糖、血压和血脂的影响：单盲、安慰剂对照试验。","authors":"Zahra Memariani, Mahin Tatari, Maryam Zahedi, Zahra Hesari, Ali Davarian, Fatemeh Kolangi","doi":"10.1002/edm2.504","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Diabetes mellitus (DM) is a chronic metabolic disorder characterised by high blood sugar (BS) levels due to impaired insulin production or insulin resistance. It is a global health concern with significant implications for morbidity and mortality. Persian medicine has long utilised natural remedies, such as <i>Pistacia atlantica</i> Desf., for various diseases. In this randomised clinical trial, the effects of <i>P. atlantica</i> oleoresin in the improvement of lipid profiles, glucose indices and blood pressure (BP) were assessed in patients with Type 2 DM.</p>\n </section>\n \n <section>\n \n <h3> Materials and Methods</h3>\n \n <p>In this randomised, single-blind, placebo-controlled study, 42 patients with Type 2 DM were randomly allocated to receive either <i>P. atlantica</i> oleoresin or placebo capsule for 3 months. Patients were evaluated prior to and 12 weeks after the beginning of the intervention, in terms of changes in lipid profiles, glucose indices and BP.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>After 3 months, the mean BP in patients with DM receiving <i>P. atlantica</i> oleoresin was significantly reduced compared with the baseline (<i>p</i> = 0.001). Also, these changes were significantly higher than those of the control group. The mean of total cholesterol (<i>p</i> = 0.89), low-density lipoprotein (LDL) (<i>p</i> = 0.43) and triglyceride (TG) (<i>p</i> = 0.98) in the intervention group after 3 months was lower than that in the control group, but this difference was not statistically significant.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>After 3 months, there was no significant difference between the <i>P. atlantica</i> and control groups in terms of blood sugar and lipid profiles. The mean BP in patients with DM receiving <i>P. atlantica</i> oleoresin was significantly reduced compared with that in the beginning of the study. Also, these changes were significant compared with the control group.</p>\n </section>\n </div>","PeriodicalId":36522,"journal":{"name":"Endocrinology, Diabetes and Metabolism","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11180711/pdf/","citationCount":"0","resultStr":"{\"title\":\"Evaluation of the Effect of Pistacia atlantica Oleoresin on Blood Sugar, Pressure and Lipids in Patients With Type 2 Diabetes: A Single-Blind, Placebo-Controlled Trial\",\"authors\":\"Zahra Memariani, Mahin Tatari, Maryam Zahedi, Zahra Hesari, Ali Davarian, Fatemeh Kolangi\",\"doi\":\"10.1002/edm2.504\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Diabetes mellitus (DM) is a chronic metabolic disorder characterised by high blood sugar (BS) levels due to impaired insulin production or insulin resistance. It is a global health concern with significant implications for morbidity and mortality. Persian medicine has long utilised natural remedies, such as <i>Pistacia atlantica</i> Desf., for various diseases. In this randomised clinical trial, the effects of <i>P. atlantica</i> oleoresin in the improvement of lipid profiles, glucose indices and blood pressure (BP) were assessed in patients with Type 2 DM.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Materials and Methods</h3>\\n \\n <p>In this randomised, single-blind, placebo-controlled study, 42 patients with Type 2 DM were randomly allocated to receive either <i>P. atlantica</i> oleoresin or placebo capsule for 3 months. Patients were evaluated prior to and 12 weeks after the beginning of the intervention, in terms of changes in lipid profiles, glucose indices and BP.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>After 3 months, the mean BP in patients with DM receiving <i>P. atlantica</i> oleoresin was significantly reduced compared with the baseline (<i>p</i> = 0.001). Also, these changes were significantly higher than those of the control group. The mean of total cholesterol (<i>p</i> = 0.89), low-density lipoprotein (LDL) (<i>p</i> = 0.43) and triglyceride (TG) (<i>p</i> = 0.98) in the intervention group after 3 months was lower than that in the control group, but this difference was not statistically significant.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>After 3 months, there was no significant difference between the <i>P. atlantica</i> and control groups in terms of blood sugar and lipid profiles. The mean BP in patients with DM receiving <i>P. atlantica</i> oleoresin was significantly reduced compared with that in the beginning of the study. Also, these changes were significant compared with the control group.</p>\\n </section>\\n </div>\",\"PeriodicalId\":36522,\"journal\":{\"name\":\"Endocrinology, Diabetes and Metabolism\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-06-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11180711/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrinology, Diabetes and Metabolism\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/edm2.504\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrinology, Diabetes and Metabolism","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/edm2.504","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Evaluation of the Effect of Pistacia atlantica Oleoresin on Blood Sugar, Pressure and Lipids in Patients With Type 2 Diabetes: A Single-Blind, Placebo-Controlled Trial
Background
Diabetes mellitus (DM) is a chronic metabolic disorder characterised by high blood sugar (BS) levels due to impaired insulin production or insulin resistance. It is a global health concern with significant implications for morbidity and mortality. Persian medicine has long utilised natural remedies, such as Pistacia atlantica Desf., for various diseases. In this randomised clinical trial, the effects of P. atlantica oleoresin in the improvement of lipid profiles, glucose indices and blood pressure (BP) were assessed in patients with Type 2 DM.
Materials and Methods
In this randomised, single-blind, placebo-controlled study, 42 patients with Type 2 DM were randomly allocated to receive either P. atlantica oleoresin or placebo capsule for 3 months. Patients were evaluated prior to and 12 weeks after the beginning of the intervention, in terms of changes in lipid profiles, glucose indices and BP.
Results
After 3 months, the mean BP in patients with DM receiving P. atlantica oleoresin was significantly reduced compared with the baseline (p = 0.001). Also, these changes were significantly higher than those of the control group. The mean of total cholesterol (p = 0.89), low-density lipoprotein (LDL) (p = 0.43) and triglyceride (TG) (p = 0.98) in the intervention group after 3 months was lower than that in the control group, but this difference was not statistically significant.
Conclusion
After 3 months, there was no significant difference between the P. atlantica and control groups in terms of blood sugar and lipid profiles. The mean BP in patients with DM receiving P. atlantica oleoresin was significantly reduced compared with that in the beginning of the study. Also, these changes were significant compared with the control group.
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