原发性和继发性登革热感染中的不同炎症标记物:细胞因子 CXCL5、CXCL9 和 CCL17 能否作为替代标记物?

IF 4.9 4区 医学 Q1 PARASITOLOGY
Pathogens and Global Health Pub Date : 2024-07-01 Epub Date: 2024-06-17 DOI:10.1080/20477724.2024.2365581
Zeeshan Mustafa, Haris Manzoor Khan, Syed Ghazanfar Ali, Hiba Sami, Ahmad Almatroudi, Masood Alam Khan, Arif Khan, Wafa Abdullah I Al-Megrin, Khaled S Allemailem, Islam Ahmad, Asmaa El-Kady, Mohammed Suliman Al-Muzaini, Mohammad Azam Khan, Mohd Azam
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引用次数: 0

摘要

登革热对全球健康构成重大威胁,其症状包括登革出血热和登革休克综合征。印度每年都会爆发表现严重的致命登革热疫情。登革热严重炎症反应的主要原因是细胞因子风暴。由于抗体依赖性增强,继发感染不同血清型登革热的患者出现并发症的风险会增加。因此,确定潜在的风险因素和生物标志物对有效控制疾病至关重要。在本研究中,我们评估了印度阿里加尔及其周边地区的登革热感染率,探讨了包括 CXCL5、CXCL9 和 CCL17 在内的细胞因子在原发性和继发性登革热感染中的作用,并将它们与各种临床指标联系起来。在 1,500 例疑似登革热病例中,有 367 例通过实时 PCR 和 ELISA 检测出登革热阳性。在继发性登革热感染中,血清中 CXCL5、CXCL9 和 CCL17 的水平明显高于原发性感染(P<0.05)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Distinct inflammatory markers in primary and secondary dengue infection: can cytokines CXCL5, CXCL9, and CCL17 act as surrogate markers?

Dengue fever poses a significant global health threat, with symptoms including dengue hemorrhagic fever and dengue shock syndrome. Each year, India experiences fatal dengue outbreaks with severe manifestations. The primary cause of severe inflammatory responses in dengue is a cytokine storm. Individuals with a secondary dengue infection of a different serotype face an increased risk of complications due to antibody-dependent enhancement. Therefore, it is crucial to identify potential risk factors and biomarkers for effective disease management. In the current study, we assessed the prevalence of dengue infection in and around Aligarh, India, and explored the role of cytokines, including CXCL5, CXCL9, and CCL17, in primary and secondary dengue infections, correlating them with various clinical indices. Among 1,500 suspected cases, 367 tested positive for dengue using Real-Time PCR and ELISA. In secondary dengue infections, the serum levels of CXCL5, CXCL9, and CCL17 were significantly higher than in primary infections (P < 0.05). Dengue virus (DENV)-2 showed the highest concentrations of CXCL5 and CCL17, whereas DENV-1 showed the highest concentrations of CXCL9. Early detection of these cytokines could serve as potential biomarkers for diagnosing severe dengue, and downregulation of these cytokines may prove beneficial for the treatment of severe dengue infections.

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来源期刊
Pathogens and Global Health
Pathogens and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-PARASITOLOGY
CiteScore
6.00
自引率
0.00%
发文量
60
审稿时长
6-12 weeks
期刊介绍: Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.
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