opisthorchiids 及其最终宿主体内的微RNA：现状与展望

IF 1.4 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular and biochemical parasitology Pub Date : 2024-06-14 DOI:10.1016/j.molbiopara.2024.111636

Xiang Li , Jian Ding , Xiaoli Zhang , Xueli Zhang , Xu Jiang , Rui Chen , Yang Cheng , Yifan Sun , Jie Wan , Yu Zhang , Jianping Cao , Su Han

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引用次数: 0

摘要

Opisthorchis felineus、Opisthorchis viverrini 和 Clonorchis sinensis（Opisthorchiidae 科）是对某些国家的人类构成严重威胁的寄生扁形虫，可引起 opisthorchis/clonorchiasis。Opisthorchiid flukes 寄生于宿主的胆道，引起胆管炎、胆囊炎、胆石症和胆管癌。在这篇综述中，我们主要关注最近对口足吸虫及其最终宿主的微RNAs（miRNAs）研究。许多 miRNAs 在三种 opisthorchiid flukes 中是保守的，并以特定发育阶段的方式表达，它们在 Opisthorchiidae 的生长发育以及宿主与病原体的相互作用中发挥着重要作用。一些 miRNA 可能是与胆管癌发生有关的潜在生物标志物。因此，这篇综述为进一步研究 miRNAs 在 opisthorchiid flukes 及其最终宿主中的作用以及促进开发预防和治疗 opisthorchiasis/clonorchiasis 的新方法奠定了基础。

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MicroRNAs in opisthorchiids and their definitive hosts: Current Status and Perspectives

Opisthorchis felineus, Opisthorchis viverrini, and Clonorchis sinensis (family Opisthorchiidae) are parasitic flatworms that pose serious threats to humans in certain countries and cause opisthorchiasis/clonorchiasis. Opisthorchiid flukes parasitize the biliary tract of the host, causing cholangitis, cholecystitis, cholelithiasis and cholangiocarcinoma. In this review, we primarily focus on recent microRNAs (miRNAs) studies of opisthorchiid flukes and their definitive hosts. Many miRNAs are conserved and expressed in a developmentally stage specific manner in the three opisthorchiid flukes, which play important roles in the growth and development of Opisthorchiidae spp., as well as host-pathogen interactions. Some miRNAs might be potential biomarkers related to carcinogenesis of cholangiocarcinoma. Therefore, this review provides the basis for further investigating the roles of miRNAs in opisthorchiid flukes and their definitive hosts, as well as promoting the development of novel approaches to prevent and treat opisthorchiasis/clonorchiasis.

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来源期刊

Molecular and biochemical parasitology 医学-寄生虫学

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

63 days

期刊介绍： The journal provides a medium for rapid publication of investigations of the molecular biology and biochemistry of parasitic protozoa and helminths and their interactions with both the definitive and intermediate host. The main subject areas covered are: • the structure, biosynthesis, degradation, properties and function of DNA, RNA, proteins, lipids, carbohydrates and small molecular-weight substances • intermediary metabolism and bioenergetics • drug target characterization and the mode of action of antiparasitic drugs • molecular and biochemical aspects of membrane structure and function • host-parasite relationships that focus on the parasite, particularly as related to specific parasite molecules. • analysis of genes and genome structure, function and expression • analysis of variation in parasite populations relevant to genetic exchange, pathogenesis, drug and vaccine target characterization, and drug resistance. • parasite protein trafficking, organelle biogenesis, and cellular structure especially with reference to the roles of specific molecules • parasite programmed cell death, development, and cell division at the molecular level.