Elena Gavrilita, Simona Ioana Silion, Miruna Lorelei Bitca, Alin Laurentiu Tatu
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引用次数: 0
摘要
特应性皮炎(AD)是一种常见的炎症性疾病,通常始于儿童早期,但越来越多的患者开始发病,甚至是老年人。根据免疫球蛋白 E(IgE)水平和临床特征,这种疾病被分为两个亚型:内在型和外在型。说到 AD,大多数专家都会想到丝胶蛋白(FLG)突变导致的表皮屏障缺陷,这也是大多数特应性患者的情况,但也有一些患者的表皮屏障正常(如影像学所见),但仍有特定的临床病变和金属过敏。在这种特殊形式的 AD 中,特定分子(IL-10、IFN-γ 和 HBD-3)已被证明会对内外因素之间的相互作用产生重大影响。一种不太为人所知的蛋白质--超级蛋白(suprabasin)已被强调为内在性AD中镍异常的一种有希望的解释。
Insights into Intrinsic Atopic Dermatitis: immunogenicity, Dysbiosis, and Imaging (Reflectance Confocal Microscopy, Optical Coherence Tomography).
Atopic dermatitis (AD) is a frequent inflammatory condition that usually begins during early childhood, but it increasingly starts to debut, even in the elderly. Based on immunoglobulin E (IgE) levels and clinical features, two subsets of this disease have been recognized: intrinsic and extrinsic. When speaking about AD, most specialists think about filaggrin (FLG) mutations resulting in epidermal barrier defects, which is the case in most atopic patients, but some have a normal barrier, as seen by imaging, and still have specific clinical lesions along with metal allergies. Specific molecules (IL-10, IFN-γ, and HBD-3) have been shown to greatly impact the interactions between internal and external factors in this peculiar form of AD. A less-known protein, suprabasin, has been highlighted as a promising explanation for nickel anomalies in intrinsic AD.
期刊介绍:
Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal.
Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest.
The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care.
All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.