Mostafa Abbasi Dezfouly, Aamir Jeewa, Andrea Maurich, Osami Honjo, Tara Pidborochynski, Holger Buchholz, Jennifer Conway
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Malnutrition was defined using the American Society of Parenteral and Enteral Nutrition guidelines as well as the Michigan MTool.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>There were 76 patients with a median age at implant of 0.9 years (IQR 0.4, 3.6), 50% male, with 73.7% having non-congenital heart disease. More than one-quarter (26.3%) of patients developed a cannula infection. Higher pre-implant weight (OR = 1.93, <i>p</i> = 0.05), creatinine (OR = 1.02, <i>p</i> = 0.044), and pre-albumin (OR = 15.79, <i>p</i> = 0.025), as well as duration of VAD support (OR = 1.01; <i>p</i> = 0.003) were associated with increased odds of developing a cannula infection. There was no difference in the malnutrition parameters between those with and without an infection.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Further exploration in a larger cohort is needed to see whether these associations remain and if the incorporation of objective measures of nutritional status at the time of infection are predictive.</p>\n </section>\n </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aor.14810","citationCount":"0","resultStr":"{\"title\":\"Nutritional status and cannula infections in pediatric patients on ventricular assist device support\",\"authors\":\"Mostafa Abbasi Dezfouly, Aamir Jeewa, Andrea Maurich, Osami Honjo, Tara Pidborochynski, Holger Buchholz, Jennifer Conway\",\"doi\":\"10.1111/aor.14810\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Ventricular assist devices (VADs) are used to bridge pediatric patients to heart transplantation. 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引用次数: 0
摘要
背景:心室辅助装置(VAD)是儿科患者接受心脏移植的桥梁。体外辅助心脏起搏器需要放置插管,这就为感染创造了环境。我们研究了儿科 VAD 患者的插管感染情况以及营养状况的作用:这项回顾性研究(2005-2021 年)纳入了患者:共有 76 名患者,植入时的中位年龄为 0.9 岁(IQR 0.4,3.6),50% 为男性,73.7% 患有非先天性心脏病。超过四分之一(26.3%)的患者出现插管感染。植入前体重(OR = 1.93,p = 0.05)、肌酐(OR = 1.02,p = 0.044)和白蛋白(OR = 15.79,p = 0.025)较高以及 VAD 支持时间较长(OR = 1.01; p = 0.003)与发生插管感染的几率增加有关。感染者和未感染者的营养不良参数没有差异:需要在更大的队列中进一步探讨这些关联是否仍然存在,以及感染时营养状况的客观指标是否具有预测作用。
Nutritional status and cannula infections in pediatric patients on ventricular assist device support
Background
Ventricular assist devices (VADs) are used to bridge pediatric patients to heart transplantation. Paracorporeal VADs require the placement of cannulas, which can create an environment for infections. We examined cannula infections in pediatric VAD patients and the role of nutritional status.
Methods
This retrospective study (2005–2021) included patients <20 years old on VAD support using Berlin Heart EXCOR® cannulas. Cannula infections were defined by a positive culture and need for antibiotic therapy. Malnutrition was defined using the American Society of Parenteral and Enteral Nutrition guidelines as well as the Michigan MTool.
Results
There were 76 patients with a median age at implant of 0.9 years (IQR 0.4, 3.6), 50% male, with 73.7% having non-congenital heart disease. More than one-quarter (26.3%) of patients developed a cannula infection. Higher pre-implant weight (OR = 1.93, p = 0.05), creatinine (OR = 1.02, p = 0.044), and pre-albumin (OR = 15.79, p = 0.025), as well as duration of VAD support (OR = 1.01; p = 0.003) were associated with increased odds of developing a cannula infection. There was no difference in the malnutrition parameters between those with and without an infection.
Conclusions
Further exploration in a larger cohort is needed to see whether these associations remain and if the incorporation of objective measures of nutritional status at the time of infection are predictive.
期刊介绍:
Artificial Organs is the official peer reviewed journal of The International Federation for Artificial Organs (Members of the Federation are: The American Society for Artificial Internal Organs, The European Society for Artificial Organs, and The Japanese Society for Artificial Organs), The International Faculty for Artificial Organs, the International Society for Rotary Blood Pumps, The International Society for Pediatric Mechanical Cardiopulmonary Support, and the Vienna International Workshop on Functional Electrical Stimulation. Artificial Organs publishes original research articles dealing with developments in artificial organs applications and treatment modalities and their clinical applications worldwide. Membership in the Societies listed above is not a prerequisite for publication. Articles are published without charge to the author except for color figures and excess page charges as noted.