线粒体 DNA 复制的启动。

IF 3.8 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical Society transactions Pub Date : 2024-06-26 DOI:10.1042/BST20230952

Yi Liu, Haibin Liu, Fan Zhang, Hong Xu

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引用次数: 0

摘要

线粒体 DNA 复制是由线粒体 RNA 聚合酶（mtRNAP）转录启动的，因为线粒体缺乏专用的引物酶。然而，决定线粒体 DNA（mtDNA）复制的 RNA 引物在连续转录和提前终止之间切换的机制仍不清楚。mtRNAP 的五叉肽重复结构域具有外切核酸酶活性，这是果蝇启动 mtDNA 复制所必需的。在这篇综述中，我们将解释这种外切核酸酶活性是如何在链耦合 mtDNA 复制中促进引物合成的，并讨论其调控是如何协调果蝇和哺乳动物中的 mtDNA 复制和转录的。

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The initiation of mitochondrial DNA replication.

Mitochondrial DNA replication is initiated by the transcription of mitochondrial RNA polymerase (mtRNAP), as mitochondria lack a dedicated primase. However, the mechanism determining the switch between continuous transcription and premature termination to generate RNA primers for mitochondrial DNA (mtDNA) replication remains unclear. The pentatricopeptide repeat domain of mtRNAP exhibits exoribonuclease activity, which is required for the initiation of mtDNA replication in Drosophila. In this review, we explain how this exonuclease activity contributes to primer synthesis in strand-coupled mtDNA replication, and discuss how its regulation might co-ordinate mtDNA replication and transcription in both Drosophila and mammals.

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来源期刊

Biochemical Society transactions 生物-生化与分子生物学

CiteScore

7.80

自引率

0.00%

发文量

351

审稿时长

3-6 weeks

期刊介绍： Biochemical Society Transactions is the reviews journal of the Biochemical Society. Publishing concise reviews written by experts in the field, providing a timely snapshot of the latest developments across all areas of the molecular and cellular biosciences. Elevating our authors’ ideas and expertise, each review includes a perspectives section where authors offer comment on the latest advances, a glimpse of future challenges and highlighting the importance of associated research areas in far broader contexts.