[胃神经内分泌肿瘤的特征与 PDX-1 转录因子的表达】。］

Q4 Medicine

Arkhiv patologii Pub Date : 2024-01-01 DOI:10.17116/patol20248603112

L E Gurevich, O A Vasyukova, L M Mikhaleva, E V Bondarenko, V E Shikina

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引用次数: 0

摘要

摘要研究胃神经内分泌肿瘤（NET）的特征以及PDX-1在其中表达的诊断和预后意义。材料与方法：对56名男性和115名女性（59人患有多发性NET）的207例NET以及94例胃癌（对比组）进行形态学和免疫组化研究：超过一半的病例（54.93%）的NET位于胃体；胃的心区和前区分别占8.64%和11.73%。心脏部位的NET以男性居多，胃体和胃窦部位的NET以女性居多。男性以心脏部位的NET为主，女性则以胃体和胃窦部位的NET为主。绝大多数NET属于高分化癌（89.20%），其中1级、2级和3级分别占55.41%、40.76%和3.82%。神经内分泌癌（NEC）占所有NET病例的10.80%。NEC多发于胃的心脏部位，占心脏部位所有NET的35.71%。在胃窦部的所有 NET 中，NEC 占 15.79%，而在胃体中仅占 3.37%。17.90%的NET发现了转移。44.73%的NET、70%的NEC和74.50%的胃癌都检测到了PDX-1的表达：结论：PDX-1参与了胃癌前病变和癌变的发生机制，在大多数恶性NET和胃癌中都检测到了PDX-1的过表达。

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[Characteristics of gastric neuroendocrine tumors and the PDX-1 transcription factor expression].

Objective: To study the features of gastric neuroendocrine tumors (NETs) and the diagnostic and prognostic significance of PDX-1 expression in them.

Material and methods: 207 NETs identified in 56 men and 115 women (59 had multiple NETs), and 94 cases of gastric cancer (comparison group) were studied morphologically and immunohistochemically.

Results: In more than half of the cases (54.93%), NETs were localized in the body of the stomach; the cardiac and antral parts of the stomach accounted for 8.64% and 11.73%, respectively. NETs of the cardiac region predominated in men, and of the body and antrum - in women. NETs of the cardiac region predominated in men, and of the body and antrum - in women. The vast majority of NETs were highly differentiated (89.20%), of which Grade 1, 2 and 3 were 55.41%, 40.76% and 3.82%, respectively. Neuroendocrine carcinomas (NEC) accounted for 10.80% of all NET cases. NECs were more often localized in the cardiac part of the stomach and accounted for 35.71% of all NETs in the cardiac part. The share of NEC among all NETs of the antrum was 15.79%, of the body of the stomach - only 3.37%. Metastases were found in 17.90% of NETs. Expression of PDX-1 was detected in 44.73% of NETs, 70% of NECs and 74.50% of gastric cancers.

Conclusion: PDX-1 is involved in the mechanisms of precancerous and cancerous lesions of the stomach and its overexpression is detected in the majority of the most malignant NETs and gastric cancers.

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来源期刊

Arkhiv patologii Medicine-Pathology and Forensic Medicine

CiteScore

0.90

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0.00%

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期刊介绍： The journal deals with original investigations on pressing problems of general pathology and pathologic anatomy, newest research methods, major issues of the theory and practice as well as problems of experimental, comparative and geographic pathology. To inform readers latest achievements of Russian and foreign medicine the journal regularly publishes editorial and survey articles, reviews of the most interesting Russian and foreign books on pathologic anatomy, new data on modern methods of investigation (histochemistry, electron microscopy, autoradiography, etc.), about problems of teaching, articles on the history of pathological anatomy development both in Russia and abroad.