新器官受累是否应纳入 PSMA 成像的反应评估标准?

IF 2.5 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
İhsan Kaplan, Halil Kömek, Canan Can, Nadiye Akdeniz, Yunus Güzel, Ferat Kepenek, Ayhan Şenol, Serdar İleri, Hüseyin Karaoğlan, İhsan Solmaz, Mehmet Serdar Yıldırım, Veysi Şenses, Fulya Kaya, Cihan Gündoğan
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引用次数: 0

摘要

目的:本研究旨在调查新器官受累对总生存期(OS)的影响,并通过将新器官受累纳入RECIP 1.0来修改PSMA影像学反应评估标准(RECIP):这项回顾性研究纳入了2017年9月至2022年6月期间诊断为转移性去势抵抗性前列腺癌(mCRPC)的114例患者,这些患者接受了多西他赛治疗,并具有基线和治疗后前列腺特异性膜抗原(PSMA)正电子发射断层扫描/计算机断层扫描(PET/CT)图像。纳入标准是具有治疗前和治疗后[18F]FDG PET/CT 图像且[18F]FDG PET 图像为阴性的患者。数据不详、患有其他恶性肿瘤或接受过阿比特龙、恩扎鲁胺或镥(Lu)-177 治疗的患者不在纳入之列。记录了每位患者的年龄、格里森评分(GS)、TPSA(总前列腺特异性抗原)水平、手术史和OS信息:114名患者的中位年龄为72.5(51-91)岁,中位GS为8(7-10)分。59名患者(51.7%)出现新病灶,14名患者(12.2%)出现新的器官PSMA摄取。在多变量考克斯回归分析中,基于容积的治疗反应(vTR)-总病灶 PSMA(TLP)、RECIP PSMA-VOL、改良 RECIP(mRECIP)PSMA-VOL 和 mRECIP TLP 是死亡率的独立预后因素(p 结论:该研究得出结论,新器官受累是导致癌症死亡的重要因素:该研究认为,新器官受累的 OS 短于新病灶受累的 OS。在我们开发的 mRECIP 中,与 RECIP 不同的是,我们证明 PSMA-VOL 和 TLP 值都是死亡率的独立预后因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Should new organ involvement be included in Response Evaluation Criteria in PSMA Imaging?

Should new organ involvement be included in Response Evaluation Criteria in PSMA Imaging?

Purpose

The current study is intended to investigate the effect of new organ involvement on overall survival (OS) and modify the Response Evaluation Criteria in PSMA Imaging (RECIP) by including new organ involvement to RECIP 1.0.

Materials and methods

This retrospective study includes 114 patients diagnosed with metastatic castration-resistant prostate cancer (mCRPC) between September 2017 and June 2022 who had received docetaxel treatment and had baseline and post-treatment prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) images. The inclusion criteria were patients with pre- and post-treatment [18F]FDG PET/CT images and whose [18F]FDG PET images were negative. Those whose data were unavailable, who had additional malignancy, or who received abiraterone, enzalutamide, or Lutetium (Lu)-177 treatment were excluded. Age, Gleason score (GS), TPSA (total prostate-specific antigen) levels, surgical history, and OS information were recorded for each patient.

Results

The 114 patients herein had a median age of 72.5 (51–91) years and a median GS of 8 (7–10). New lesions were observed in 59 patients (51.7%) and new organ PSMA uptake was observed in 14 patients (12.2%). In the multivariate Cox regression analysis, volume-based treatment response (vTR)-total lesion PSMA (TLP), RECIP PSMA-VOL, modified RECIP (mRECIP) PSMA-VOL, and mRECIP TLP were independent prognostic factors for mortality (p < 0.001, p = 0.006, p = 0.003, and p = 0.003, respectively). The median OS of patients with new organ involvement and new lesion with PSMA uptake was 9.3 months (95% CI 2.1–16.5 months) and 11.8 months (95% CI 7.4–16.2 months), respectively.

Conclusion

The study concluded that new organ involvement had a shorter OS than new lesion involvement. In the mRECIP that we developed, unlike RECIP, we demonstrated that both PSMA-VOL and TLP value were independent prognostic factors for mortality.

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来源期刊
Annals of Nuclear Medicine
Annals of Nuclear Medicine 医学-核医学
CiteScore
4.90
自引率
7.70%
发文量
111
审稿时长
4-8 weeks
期刊介绍: Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine. The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.
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