补充蜂胶对患有代谢综合征及相关疾病的成年人血脂状况的影响:随机对照试验的系统回顾和荟萃分析

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM
Yasmin Basheer Ahmed , Saade Abdalkareem Jasim , Yasser Fakri Mustafa , Beneen Husseen , Thoraya Mahbas Diwan , Mandeep Singh
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引用次数: 0

摘要

背景和目的关于蜂胶补充剂对患有代谢综合征(MetS)和相关疾病的成年人血脂状况的影响,研究结果相互矛盾。方法在PubMed、Scopus、Web of Science和Cochrane图书馆等在线数据库中搜索了截至2024年5月的随机对照试验(RCT),这些试验研究了补充蜂胶对患有代谢综合征和相关疾病的成年人血脂状况的影响。采用随机效应模型对数据进行了汇总,并以加权平均差(WMD)和95%置信区间(CI)表示。综合结果显示,补充蜂胶可显著降低低密度脂蛋白胆固醇(LDL-C)水平(WMD:-7.97 mg/dL,95 % CI:-13.11 to -2.83,P = 0.002;I2 = 69.9 %),高密度脂蛋白胆固醇(HDL-C)水平显著增加(WMD:2.85 mg/dL,95 % CI:0.41 to 5.28,P = 0.02;I2 = 82.2 %)。然而,对甘油三酯(WMD:-9.12 mg/dL,95 % CI:-22.84 至 4.59,P = 0.19;I2 = 0.0 %)和总胆固醇水平(WMD:0.69 mg/dL;95 % CI:-4.结论这项荟萃分析表明,补充蜂胶可改善血清低密度脂蛋白胆固醇和高密度脂蛋白胆固醇水平,从而延缓心脏病的进展。然而,这些结果是基于有限的临床试验得出的,还需要进一步的临床试验来专门研究蜂胶对血脂异常患者的影响,以证实我们的研究结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The effects of propolis supplementation on lipid profiles in adults with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials

The effects of propolis supplementation on lipid profiles in adults with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials

Background and aim

Findings on the effects of propolis supplementation on the lipid profile in adults with metabolic syndrome (MetS) and related disorders are conflicting. The current comprehensive systematic review and meta-analysis aimed to summarize available evidence in this regard.

Methods

Online databases including PubMed, Scopus, Web of Science, and Cochrane Library were searched up to May 2024 for randomized controlled trials (RCTs) that examined the effect of propolis supplementation on lipid profile in adults with MetS and related disorders. The data was pooled using a random-effects model and is presented as weighted mean difference (WMD) with a 95 % confidence interval (CI).

Results

Ten RCTs involving a total of 683 subjects were included in this meta-analysis. The combined results revealed that propolis supplementation led to a significant decrease in low-density lipoprotein cholesterol (LDL-C) levels (WMD: −7.97 mg/dL, 95 % CI: −13.11 to −2.83, P = 0.002; I2 = 69.9 %) and a significant increase in high-density lipoprotein cholesterol (HDL-C) levels (WMD: 2.85 mg/dL, 95 % CI: 0.41 to 5.28, P = 0.02; I2 = 82.2 %). However, there was no significant impact on triglyceride (WMD: −9.12 mg/dL, 95 % CI: −22.84 to 4.59, P = 0.19; I2 = 0.0 %) and total cholesterol levels (WMD: 0.69 mg/dL; 95 % CI: −4.79 to 6.18, P = 0.80; I2 = 81.9 %).

Conclusions

This meta-analysis suggests that propolis supplementation improves serum LDL-C and HDL-C levels, which could delay the progression of heart disease. However, these results were based on limited RCTs, and further clinical trials are needed to exclusively study the effects of propolis on individuals with dyslipidemia to confirm our findings.

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来源期刊
Human Nutrition and Metabolism
Human Nutrition and Metabolism Agricultural and Biological Sciences-Food Science
CiteScore
1.50
自引率
0.00%
发文量
30
审稿时长
188 days
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