干浸法迅速干扰男性和女性的铁代谢：VIVALDI 研究的结果。

IF 4.4 1区物理与天体物理 Q1 MULTIDISCIPLINARY SCIENCES

npj Microgravity Pub Date : 2024-06-15 DOI:10.1038/s41526-024-00399-z

Mathieu Horeau, Nastassia Navasiolava, Angelique Van Ombergen, Marc-Antoine Custaud, Adrien Robin, Martine Ropert, Inês Antunes, Marie-Pierre Bareille, Rebecca Billette De Villemeur, Guillemette Gauquelin-Koch, Frédéric Derbré, Olivier Loréal

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引用次数: 0

摘要

铁是细胞呼吸、肌肉代谢和氧气运输所必需的。最新研究表明，模拟微重力会迅速影响男性的铁代谢。然而，它对女性的影响仍不清楚。本研究旨在比较暴露于 5 天干燥浸泡环境中的男女两性的铁代谢变化。我们的研究结果表明，女性和男性一样，在短期暴露于模拟微重力环境后，全身铁的可用性增加，血清血红素水平升高，这表明铁的分布出现了偏差。

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Dry immersion rapidly disturbs iron metabolism in men and women: results from the VIVALDI studies.

Iron is essential for cell respiration, muscle metabolism, and oxygen transport. Recent research has shown that simulated microgravity rapidly affects iron metabolism in men. However, its impact on women remains unclear. This study aims to compare iron metabolism alterations in both sexes exposed to 5 days of dry immersion. Our findings demonstrate that women, similarly to men, experience increased systemic iron availability and elevated serum hepcidin levels, indicative of iron misdistribution after short-term exposure to simulated microgravity.

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来源期刊

npj Microgravity Physics and Astronomy-Physics and Astronomy (miscellaneous)

CiteScore

7.30

自引率

7.80%

发文量

审稿时长

9 weeks

期刊介绍： A new open access, online-only, multidisciplinary research journal, npj Microgravity is dedicated to publishing the most important scientific advances in the life sciences, physical sciences, and engineering fields that are facilitated by spaceflight and analogue platforms.