{"title":"木槿对肥胖症治疗的临床效果：随机对照试验的系统回顾和荟萃分析。","authors":"Piyameth Dilokthornsakul , Natnicha Rattanachaisit , Phiyanuch Thimkorn , Supawan Pongpattanawut , Witoo Dilokthornsakul , Teerapon Dhippayom","doi":"10.1016/j.ctim.2024.103063","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Obesity is associated with many chronic non-communicable diseases, including hypertension, diabetes, cardiovascular and cerebrovascular diseases, cancer, gallbladder disease, bone and joint disorders, skin diseases, fatty liver disease, etc. (Wharton et al., 2020)<sup>1</sup> The recent report revealed that overweight and obesity were prevalent in 60 % of the adult population. Several studies have been published to determine the effect of <em>Hibiscus sabdariffa</em> Linn. on obesity treatment, but the findings are still inconclusive. The purpose of this study was to determine the efficacy and safety of <em>H. sabdariffa</em> Linn in the treatment of obesity.</p></div><div><h3>Methods</h3><p>We searched PubMed, EMBASE, and CENTRAL from inception to February 2024. Randomized controlled trials (RCTs) were included if they explored the effect of <em>H. sabdariffa</em> on one of the following outcomes: body weight, body mass index (BMI), waist circumference, and waist-to-hip ratio. A random-effects model was used to meta-analyze the data. <em>I</em><sup><em>2</em></sup> was used to quantify statistical heterogeneity among the included RCTs. PROSPERO registered protocol: CRD42023408880.</p></div><div><h3>Results</h3><p>A total of six RCTs with 339 participants were included. Four trials used <em>H. sabdariffa</em> extract in capsules as the intervention of interest compared to placebo, while the other two trials used <em>H. sabdariffa</em> tea compared to black or green tea. Our meta-analyses showed that the mean difference in weight reduction between <em>H. sabdariffa</em> and control was − 0.27 kg (95 % confidence interval (CI); − 1.98 to 1.42, <em>I</em><sup><em>2</em></sup> = 0.0 %). The mean differences for BMI and waist circumference reduction were − 0.06 kg/m<sup>2</sup> (95 % CI; − 0.58 to 0.47, <em>I</em><sup><em>2</em></sup> = 0.0 %) and − 0.20 centimeters (95 % CI; − 2.06 to 1.66, <em>I</em><sup><em>2</em></sup> = 0.00 %). No safety concerns were reported in the included studies.</p></div><div><h3>Conclusion</h3><p>Our study did not show a clinical benefit of <em>H. sabdariffa</em> extract in obesity treatment. However, further high-quality RCTs with a longer treatment duration and a standard dose are still warranted.</p></div>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000517/pdfft?md5=1c843e4f77d265f518af87584423c6ba&pid=1-s2.0-S0965229924000517-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Clinical effects of Hibiscus sabdariffa Linn. on obesity treatment: A systematic review and meta-analysis of randomized controlled trials\",\"authors\":\"Piyameth Dilokthornsakul , Natnicha Rattanachaisit , Phiyanuch Thimkorn , Supawan Pongpattanawut , Witoo Dilokthornsakul , Teerapon Dhippayom\",\"doi\":\"10.1016/j.ctim.2024.103063\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>Obesity is associated with many chronic non-communicable diseases, including hypertension, diabetes, cardiovascular and cerebrovascular diseases, cancer, gallbladder disease, bone and joint disorders, skin diseases, fatty liver disease, etc. (Wharton et al., 2020)<sup>1</sup> The recent report revealed that overweight and obesity were prevalent in 60 % of the adult population. Several studies have been published to determine the effect of <em>Hibiscus sabdariffa</em> Linn. on obesity treatment, but the findings are still inconclusive. The purpose of this study was to determine the efficacy and safety of <em>H. sabdariffa</em> Linn in the treatment of obesity.</p></div><div><h3>Methods</h3><p>We searched PubMed, EMBASE, and CENTRAL from inception to February 2024. Randomized controlled trials (RCTs) were included if they explored the effect of <em>H. sabdariffa</em> on one of the following outcomes: body weight, body mass index (BMI), waist circumference, and waist-to-hip ratio. A random-effects model was used to meta-analyze the data. <em>I</em><sup><em>2</em></sup> was used to quantify statistical heterogeneity among the included RCTs. PROSPERO registered protocol: CRD42023408880.</p></div><div><h3>Results</h3><p>A total of six RCTs with 339 participants were included. Four trials used <em>H. sabdariffa</em> extract in capsules as the intervention of interest compared to placebo, while the other two trials used <em>H. sabdariffa</em> tea compared to black or green tea. Our meta-analyses showed that the mean difference in weight reduction between <em>H. sabdariffa</em> and control was − 0.27 kg (95 % confidence interval (CI); − 1.98 to 1.42, <em>I</em><sup><em>2</em></sup> = 0.0 %). The mean differences for BMI and waist circumference reduction were − 0.06 kg/m<sup>2</sup> (95 % CI; − 0.58 to 0.47, <em>I</em><sup><em>2</em></sup> = 0.0 %) and − 0.20 centimeters (95 % CI; − 2.06 to 1.66, <em>I</em><sup><em>2</em></sup> = 0.00 %). No safety concerns were reported in the included studies.</p></div><div><h3>Conclusion</h3><p>Our study did not show a clinical benefit of <em>H. sabdariffa</em> extract in obesity treatment. However, further high-quality RCTs with a longer treatment duration and a standard dose are still warranted.</p></div>\",\"PeriodicalId\":3,\"journal\":{\"name\":\"ACS Applied Electronic Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-06-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0965229924000517/pdfft?md5=1c843e4f77d265f518af87584423c6ba&pid=1-s2.0-S0965229924000517-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Electronic Materials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0965229924000517\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0965229924000517","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
Clinical effects of Hibiscus sabdariffa Linn. on obesity treatment: A systematic review and meta-analysis of randomized controlled trials
Introduction
Obesity is associated with many chronic non-communicable diseases, including hypertension, diabetes, cardiovascular and cerebrovascular diseases, cancer, gallbladder disease, bone and joint disorders, skin diseases, fatty liver disease, etc. (Wharton et al., 2020)1 The recent report revealed that overweight and obesity were prevalent in 60 % of the adult population. Several studies have been published to determine the effect of Hibiscus sabdariffa Linn. on obesity treatment, but the findings are still inconclusive. The purpose of this study was to determine the efficacy and safety of H. sabdariffa Linn in the treatment of obesity.
Methods
We searched PubMed, EMBASE, and CENTRAL from inception to February 2024. Randomized controlled trials (RCTs) were included if they explored the effect of H. sabdariffa on one of the following outcomes: body weight, body mass index (BMI), waist circumference, and waist-to-hip ratio. A random-effects model was used to meta-analyze the data. I2 was used to quantify statistical heterogeneity among the included RCTs. PROSPERO registered protocol: CRD42023408880.
Results
A total of six RCTs with 339 participants were included. Four trials used H. sabdariffa extract in capsules as the intervention of interest compared to placebo, while the other two trials used H. sabdariffa tea compared to black or green tea. Our meta-analyses showed that the mean difference in weight reduction between H. sabdariffa and control was − 0.27 kg (95 % confidence interval (CI); − 1.98 to 1.42, I2 = 0.0 %). The mean differences for BMI and waist circumference reduction were − 0.06 kg/m2 (95 % CI; − 0.58 to 0.47, I2 = 0.0 %) and − 0.20 centimeters (95 % CI; − 2.06 to 1.66, I2 = 0.00 %). No safety concerns were reported in the included studies.
Conclusion
Our study did not show a clinical benefit of H. sabdariffa extract in obesity treatment. However, further high-quality RCTs with a longer treatment duration and a standard dose are still warranted.
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