新型二氢吡啶衍生物的绿色合成与生物活性评估。

IF 1.6 4区 医学 Q4 BIOCHEMICAL RESEARCH METHODS
Nasim Khoshlahjeh Motamed, Kambiz Larijani, Elham Pournamdari, Hamid Saeidian, Fariba Zamani Hargalani
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引用次数: 0

摘要

目的和目标:本研究使用亚氨基二乙酸-抑制剂(Fe3O4@SiO2/IDA-Cu)官能化的二氧化硅包覆磁性纳米粒子,在室温水介质中进行涉及 (1E,6E)-1,7-双(4-羟基-3-甲氧基苯基)庚-1、6-二烯-3,5-二酮(莪术)、伯胺和活化乙炔化合物在水介质中于室温下进行的一锅多组分反应,并以高产率生成 1,4-二氢吡啶-2,3-二甲酸酯。该领域的进一步研究使用二苯基吡啶肼(DPPH)自由基捕获法研究生成的一些 6,6´-亚甲基双-1,4-二氢吡啶-2,3-二羧酸盐的抗氧化特性。目前正在进行的学术研究主要集中在研究已生成化学物质的抗菌特性:研究小组使用的试剂或溶剂均为分析质量,这意味着它们的物理和化学特性没有改变。使用岛津 IR-460 光谱仪记录了在 KBr 介质中制备的纳米催化剂和合成的 6,6´-亚甲基双-1,4-二氢吡啶-2,3-二羧酸盐的傅立叶变换红外光谱。此外,还使用布鲁克 DRX-400 AVANCE 光谱仪获得了所生成化合物的 1H 和 13C NMR 光谱。为了获得所生成化合物的光谱,光谱仪校准到 400 MHz,溶剂为 CDCl3,内标为 TMS。值得一提的是,所生成化合物的质谱是使用 Finnigan MAT 8430 光谱仪获得的,其电离能力为 70 eV。通过包括 X 射线衍射 (XRD)、能量色散 X 射线光谱 (EDX)、扫描电子显微镜 (SEM) 和振动样品磁力计 (VSM) 在内的光谱研究,合成催化剂 Fe3O4@SiO2@IDA-Cu 被批准建造。Finnigan-MAT 8430 光谱仪用于生成化学物质的质谱。为了确定所生成的化合物中含有哪些元素,使用了贺利氏 CHN-O-Rapid 分析仪:当前研究的重点是通过将姜黄素 1、伯胺 2 和活化乙炔化合物 3 以三组份工艺结合在一起,生成新的 6,6´-亚甲基双-1,4-二氢吡啶-2,3-二羧酸盐 4。反应是在常温下的水基溶液中进行的,使用的纳米催化剂是可多次使用的 Fe3O4@SiO2@IDA-Cu。研究结果表明,与传统抗氧化剂相比,合成的化合物具有显著的抗氧化潜力。此外,还评估了合成化合物对革兰氏阳性菌和革兰氏阴性菌的抗菌效果:总之,在常温下的水基环境中研究了姜黄素、伯胺和活化乙炔化学品的多组分反应。这些反应是使用一种名为 Fe3O4@SiO2@IDA-Cu 的新型催化剂(一种有机金属纳米催化剂)进行的。这就产生了具有抗氧化和抗菌活性的新型 6,6-亚甲基双-1,4-二氢吡啶-2,3-二羧酸盐。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
WITHDRAWN: Green Synthesis and Evaluation of the Biological Activity of New Dihydropyridine Derivatives

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been withdrawn from the journal Combinatorial Chemistry & High Throughput Screening.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham science disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

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来源期刊
CiteScore
3.10
自引率
5.60%
发文量
327
审稿时长
7.5 months
期刊介绍: Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal: Target identification and validation Assay design, development, miniaturization and comparison High throughput/high content/in silico screening and associated technologies Label-free detection technologies and applications Stem cell technologies Biomarkers ADMET/PK/PD methodologies and screening Probe discovery and development, hit to lead optimization Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries) Chemical library design and chemical diversity Chemo/bio-informatics, data mining Compound management Pharmacognosy Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products) Natural Product Analytical Studies Bipharmaceutical studies of Natural products Drug repurposing Data management and statistical analysis Laboratory automation, robotics, microfluidics, signal detection technologies Current & Future Institutional Research Profile Technology transfer, legal and licensing issues Patents.
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