LnCRNAs 在调节子宫内膜对胚胎着床的可接受性中的作用

IF 1.8 Q3 OBSTETRICS & GYNECOLOGY
Haniyeh Ebrahimnejad Hasanabadi, Azam Govahi, Shahla Chaichian, Mehdi Mehdizadeh, Ladan Haghighi, Marziyeh Ajdary
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引用次数: 0

摘要

子宫内膜接受性的发展对胚胎成功植入和开始妊娠至关重要。了解将子宫内膜转化为接受期的分子调控过程对于提高体外受精(IVF)等生育治疗中的植入率至关重要。长非编码 RNA(lncRNA)作为基因调控因子发挥着举足轻重的作用,已在子宫内膜中进行了研究。本综述介绍了目前对 lncRNA 在调节子宫内膜受孕率中的作用的见解。考虑到不同物种的子宫内膜重塑存在显著差异,我们总结了人类子宫内膜周期中的关键事件,并讨论了在人类和其他物种中已发现的lncRNAs,它们可能在建立子宫内膜接受性方面发挥着关键作用。值得注意的是,人类有 742 个 lncRNA,而有 4438 个 lncRNA 有可能调节子宫内膜的接受能力。此外,在两个物种中都观察到了调节基质金属蛋白酶(MMPs)和Let-7的lncRNAs。未来的研究应探索lncRNAs作为治疗靶点和/或生物标志物的潜力,以诊断和改善人类生育治疗中的子宫内膜接受性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
LnCRNAs in the Regulation of Endometrial Receptivity for Embryo Implantation.

The development of endometrial receptivity is crucial for successful embryo implantation and the initiation of pregnancy. Understanding the molecular regulatory processes that transform the endometrium into a receptive phase is essential for enhancing implantation rates in fertility treatments, such as in vitro fertilization (IVF). Long non-coding RNAs (lncRNAs) play a pivotal role as gene regulators and have been examined in the endometrium. This review offers current insights into the role of lncRNAs in regulating endometrial receptivity. Considering the significant variation in endometrial remodeling among species, we summarize the key events in the human endometrial cycle and discuss the identified lncRNAs in both humans and other species, which may play a crucial role in establishing receptivity. Notably, there are 742 lncRNAs in humans and 4438 lncRNAs that have the potential to modulate endometrial receptivity. Additionally, lncRNAs regulating matrix metalloproteinases (MMPs) and Let-7 have been observed in both species. Future investigations should explore the potential of lncRNAs as therapeutic targets and/or biomarkers for diagnosing and improving endometrial receptivity in human fertility therapy.

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来源期刊
CiteScore
3.30
自引率
6.70%
发文量
56
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