口服避孕药暴露与后续多发性硬化症之间无关联：一项基于人群的初级保健巢式病例对照研究。

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY

Multiple Sclerosis Journal Pub Date : 2024-08-01 Epub Date: 2024-06-14 DOI:10.1177/13524585241258691

Qiqi Zhang, Alastair J Noyce, John Robson, Gavin Giovannoni, Charles R Marshall, Ruth Dobson

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引用次数: 0

摘要

背景：口服避孕药与多发性硬化症（MS）之间存在数据冲突：关于口服避孕药暴露与多发性硬化症（MS）继发的数据存在冲突：利用常规收集的初级医疗保健数据，在人群水平上探讨口服避孕药暴露与女性多发性硬化症继发之间的潜在关联：我们利用电子初级保健数据进行了一项巢式病例对照研究，从 1990 年开始进行完整的电子确认。在不考虑或考虑年龄、种族和贫困程度的情况下，采用逻辑回归法评估避孕药暴露与多发性硬化症之间的关联：结果：共纳入 4455 名女性：结果：共纳入 4455 名女性：891 例病例和 3564 例对照。在口服避孕药暴露与随后的多发性硬化症之间，或在多发性硬化症发生前0-2年、2-5年或>5年使用任何避孕药、复方口服避孕药（COCP）或纯孕酮避孕药（POP）之间，均未发现任何关联。结论：在这项迄今为止规模最大的人群研究中，我们没有发现口服避孕药暴露与随后的多发性硬化症诊断之间存在关联的证据。

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No association between oral contraceptive exposure and subsequent MS: A population-based nested case-control study in primary care.

Background: Conflicting data exist around oral contraceptive exposure and subsequent multiple sclerosis (MS).

Objective: To use routinely collected primary healthcare data to explore the potential association between oral contraceptive exposure and subsequent MS in females at population level.

Methods: We performed a nested case-control study using electronic primary care data, with complete electronic ascertainment from 1990. Logistic regression was used to evaluate associations between contraceptive exposure and MS, without and with adjusting for age, ethnicity and deprivation.

Results: A total of 4455 females were included: 891 cases and 3564 controls. No association was seen between oral contraceptive exposure and subsequent MS, or between any contraceptive, combined oral contraceptive pill (COCP) or progesterone-only pill (POP) use 0-2, 2-5 or >5 years prior to MS. Conclusions: In the largest population-based study to date, we find no evidence of an association between oral contraceptive exposure and subsequent MS diagnosis.

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来源期刊

Multiple Sclerosis Journal 医学-临床神经学

CiteScore

10.90

自引率

6.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585