甘薯(羟基柠檬酸)对血清瘦素浓度的影响:随机对照试验的系统回顾和荟萃分析。

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
Mohammad Reza Amini , Marieh Salavatizadeh , Shervin Kazeminejad , Fozhan Javadi , Mahdi Hajiaqaei , Gholamreza Askari , Azita Hekmatdoost
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引用次数: 0

摘要

目的:所观察到的藤黄果(GC)对血清瘦素的影响并不一致。我们对随机对照试验(RCT)进行了系统回顾和荟萃分析,以评估 GC 对瘦素水平的影响:我们使用不同的在线数据库(包括 Scopus、Web of Science、PubMed 和 Google Scholar)进行了全面的文献检索,直至 2024 年 5 月 25 日。使用随机效应计算加权平均差(WMD)和相应的 95% 置信区间(CI)。在考虑发表偏倚、研究质量和统计异质性时遵循了标准程序:在这项荟萃分析中,最终共纳入了 8 项符合条件的试验,共有 330 名参与者。质量评估结果显示,一半纳入的试验被认为质量尚可,另一半被认为质量较差。我们的分析结果显示,与安慰剂相比,GC 对瘦素的影响显著降低(WMD:-5.01ng/ml;95% CI:-9.22 至-0.80,P=0.02),且无发表偏倚迹象。然而,研究之间存在明显的异质性(I2=93.5%,P<0.001)。Hartung-Knapp调整并没有影响我们的结果。亚组分析表明,在样本量≥ 50 的试验中,服用 GC 的影响最大(WMD:-3.63ng/ml;95% CI [-5.51,-1.76],p 结论:GC 对血糖的影响在样本量≥ 50 的试验中最大:本研究结果表明,服用 GC 后瘦素水平可能会下降。为了证实我们的研究结果,需要进一步开展具有合适方法学结构的高质量 RCT 研究:注册编号:CRD42023486370。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effects of Garcinia cambogia (hydroxycitric acid) on serum leptin concentrations: A systematic review and meta-analysis of randomized controlled trials

Objective

The observed impacts of Garcinia cambogia (GC) on serum leptin indicate inconsistency. We performed a systematic review and meta-analysis on randomized controlled trials (RCTs) to evaluate the effectiveness of GC on leptin levels.

Methods

A thorough literature search was carried out using different online databases, including Scopus, Web of Science, PubMed, and Google Scholar, until May 25, 2024. Using random effects, weighted mean differences (WMDs) and corresponding 95 % confidence intervals (CIs) were computed. Standard procedures were followed to account for publication bias, study quality, and statistical heterogeneity.

Results

In this meta-analysis, a total of eight eligible trials with 330 participants were ultimately included. Quality assessment showed that half of the included trials were considered to have fair quality, while the other half were deemed to have poor quality. Our analysis, with no indication of publication bias, showed a significantly decreased effect of GC on leptin compared with the placebo (WMD: −5.01 ng/ml; 95 % CI: −9.22 to −0.80, p = 0.02). However, significant heterogeneity was detected between studies (I2 =93.5 %, p < 0.001). The Hartung-Knapp adjustment did not affect our results. Subgroup analysis revealed that GC consumption represents the most effects in trials with sample size ≥ 50 (WMD: −3.63 ng/ml; 95 % CI [−5.51, −1.76], p < 0.001), and mean age of participants ≥ 30 years (WMD: −7.43 ng/ml; 95 % CI [−9.31, −5.56], p < 0.001).

Conclusions

The findings of the present study showed that leptin levels might decline following GC administration. Registration number: CRD42023486370

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CiteScore
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