突尼斯人口中的二十二碳六烯酸、二十碳五烯酸、花生四烯酸和神经管缺陷。

IF 1.6 4区医学 Q4 DEVELOPMENTAL BIOLOGY

Birth Defects Research Pub Date : 2024-06-14 DOI:10.1002/bdr2.2372

Kaouther Nasri, Nadia Ben Jamaa, Soumeya Siala Gaigi, Moncef Feki, Raja Marrakchi

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引用次数: 0

摘要

目的确定母体（血浆和红细胞）叶酸、维生素 B12、同型半胱氨酸和维生素 D 的状况及其与 MTHFR（C677T 和 A1298C）和 MTRR A66G 多态性的相互作用对母体血浆二十二碳六烯酸 (DHA)、二十碳五烯酸 (EPA) 和花生四烯酸 (ARA) 水平以及神经管畸形 (NTD) 风险的影响：方法：使用毛细管气相色谱法评估 ARA、EPA 和 DHA 的组成：在血浆叶酸水平低的情况下，对照组母亲的 ARA 和 DHA 水平高于病例母亲。在红细胞叶酸含量低的情况下，对照组的 DHA 含量高于病例母亲。在同型半胱氨酸水平较高的情况下，对照组母亲的 ARA 和 DHA 水平高于病例母亲。维生素 B12 水平低时，NTD 母亲的 EPA 和 DHA 水平较低。维生素 D 水平低时，NTD 母亲的 DHA 水平也较低。在血浆叶酸含量低的情况下，病例母亲的 MTHFR C677T 基因中的 DHA 含量以及 MTHFR A1298C 基因中的 ARA 和 EPA 含量在三种基因型之间存在差异。在同型半胱氨酸水平较低和较高的情况下，病例母亲的 MTHFR C677T 基因中的 DHA 含量在三种基因型之间存在差异。在维生素 B12 含量低的情况下，病例母亲中 MTHFR C677T 基因的三种基因型的 ARA 和 DHA 含量也不同。在维生素 D 含量低的情况下，病例母亲的 MTHFR C677T 基因的三种基因型的 ARA 和 DHA 含量也不同：结论：需要进行更深入的研究，以验证与孕妇基因型相关的适当生化参数状态。

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Docosahexaenoic acid, eicosapentaenoic acid, arachidonic acid, and neural tube defects in Tunisian population

Objective

To determine the effect of maternal status in (plasma and red blood cell) folate, vitamin B12, homocysteine, and vitamin D, as well as their interaction with MTHFR (C677T and A1298C) and MTRR A66G polymorphisms, on maternal plasma docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and arachidonic acid (ARA) levels and the risk of neural tube defects (NTDs).

Methods

ARA, EPA, and DHA composition was assessed using capillary gas chromatography.

Results

ARA and DHA levels were higher in controls than in case mothers for low plasma folate status. For low red blood cell folate status, DHA levels were higher in controls than in case mothers. For high homocysteine levels, ARA and DHA levels were higher in controls than in case mothers. NTD mothers had lower EPA and DHA levels for low vitamin B12 levels. NTD mothers had lower DHA levels for low vitamin D levels. For low plasma folate status, DHA levels in the MTHFR C677T gene and ARA and EPA levels in MTHFR A1298C gene were different among the three genotypes in case mothers. DHA levels in the MTHFR C677T gene were different among the three genotypes in case mothers for both low and high homocysteine levels. For low vitamin B12 levels, ARA and DHA levels were different among the three genotypes of the MTHFR C677T gene in case mothers. In the MTHFR C677T gene, ARA and DHA levels were different among the three genotypes in case mothers for low vitamin D levels.

Conclusions

More advanced research is required to verify a suitable biochemical parameter status in relation to the genotypes in pregnant women.

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来源期刊

Birth Defects Research Medicine-Embryology

CiteScore

3.60

自引率

9.50%

发文量

153

期刊介绍： The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.