{"title":"戊型肝炎病毒感染会上调 ING5 在体外和体内的表达。","authors":"Wanqiu Zhao, Yueping Xia, Tengyuan Li, Huichan Liu, Guo Zhong, Dongxue Chen, Wenhai Yu, Yunlong Li, Fen Huang","doi":"10.3724/abbs.2024091","DOIUrl":null,"url":null,"abstract":"<p><p>Hepatitis E virus (HEV) is the major pathogen of viral hepatitis. Immunocompromised individuals infected by HEV are prone to chronic hepatitis and increase the risk of hepato-cellular carcinoma (HCC). Inhibitor of growth family member 5 (ING5) is a tumor suppressor that is expressed at low levels in cancer tumors or cells. However, the underlying relationship between ING5 and HEV infection is unclear. In the present study, acute and chronic HEV animal models are used to explore the interaction between ING5 and HEV. Notably, the expression of ING5 is significantly increased in both the livers of acute HEV-infected BALB/c mice and chronic HEV-infected rhesus macaques. In addition, the relationship between HEV infection and ING5 expression is further identified in human hepatoma (HepG-2) cells. In conclusion, HEV infection strongly upregulates ING5 expression both <i>in vivo</i> and <i>in vitro</i>, which has significant implications for further understanding the pathogenic mechanism of HEV infection.</p>","PeriodicalId":6978,"journal":{"name":"Acta biochimica et biophysica Sinica","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532201/pdf/","citationCount":"0","resultStr":"{\"title\":\"Hepatitis E virus infection upregulates ING5 expression <i>in vitro</i> and <i>in vivo</i>.\",\"authors\":\"Wanqiu Zhao, Yueping Xia, Tengyuan Li, Huichan Liu, Guo Zhong, Dongxue Chen, Wenhai Yu, Yunlong Li, Fen Huang\",\"doi\":\"10.3724/abbs.2024091\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Hepatitis E virus (HEV) is the major pathogen of viral hepatitis. Immunocompromised individuals infected by HEV are prone to chronic hepatitis and increase the risk of hepato-cellular carcinoma (HCC). Inhibitor of growth family member 5 (ING5) is a tumor suppressor that is expressed at low levels in cancer tumors or cells. However, the underlying relationship between ING5 and HEV infection is unclear. In the present study, acute and chronic HEV animal models are used to explore the interaction between ING5 and HEV. Notably, the expression of ING5 is significantly increased in both the livers of acute HEV-infected BALB/c mice and chronic HEV-infected rhesus macaques. In addition, the relationship between HEV infection and ING5 expression is further identified in human hepatoma (HepG-2) cells. In conclusion, HEV infection strongly upregulates ING5 expression both <i>in vivo</i> and <i>in vitro</i>, which has significant implications for further understanding the pathogenic mechanism of HEV infection.</p>\",\"PeriodicalId\":6978,\"journal\":{\"name\":\"Acta biochimica et biophysica Sinica\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-06-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532201/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta biochimica et biophysica Sinica\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.3724/abbs.2024091\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta biochimica et biophysica Sinica","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3724/abbs.2024091","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
戊型肝炎病毒（HEV）是病毒性肝炎的主要病原体。感染戊型肝炎病毒的免疫力低下者易患慢性肝炎，并增加罹患肝细胞癌（HCC）的风险。生长抑素家族成员 5（ING5）是一种肿瘤抑制因子，在癌症肿瘤或细胞中的表达水平较低。然而，ING5 与 HEV 感染之间的潜在关系尚不清楚。本研究利用急性和慢性 HEV 动物模型来探讨 ING5 与 HEV 之间的相互作用。值得注意的是，在急性 HEV 感染的 BALB/c 小鼠和慢性 HEV 感染的猕猴肝脏中，ING5 的表达都明显增加。此外，在人肝癌（HepG-2）细胞中进一步确定了 HEV 感染与 ING5 表达之间的关系。总之，HEV 感染会强烈上调 ING5 在体内和体外的表达，这对进一步了解 HEV 感染的致病机制具有重要意义。
Hepatitis E virus infection upregulates ING5 expression in vitro and in vivo.
Hepatitis E virus (HEV) is the major pathogen of viral hepatitis. Immunocompromised individuals infected by HEV are prone to chronic hepatitis and increase the risk of hepato-cellular carcinoma (HCC). Inhibitor of growth family member 5 (ING5) is a tumor suppressor that is expressed at low levels in cancer tumors or cells. However, the underlying relationship between ING5 and HEV infection is unclear. In the present study, acute and chronic HEV animal models are used to explore the interaction between ING5 and HEV. Notably, the expression of ING5 is significantly increased in both the livers of acute HEV-infected BALB/c mice and chronic HEV-infected rhesus macaques. In addition, the relationship between HEV infection and ING5 expression is further identified in human hepatoma (HepG-2) cells. In conclusion, HEV infection strongly upregulates ING5 expression both in vivo and in vitro, which has significant implications for further understanding the pathogenic mechanism of HEV infection.
期刊介绍：
Acta Biochimica et Biophysica Sinica (ABBS) is an internationally peer-reviewed journal sponsored by the Shanghai Institute of Biochemistry and Cell Biology (CAS). ABBS aims to publish original research articles and review articles in diverse fields of biochemical research including Protein Science, Nucleic Acids, Molecular Biology, Cell Biology, Biophysics, Immunology, and Signal Transduction, etc.
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