治疗性微生物组调节:艾滋病治疗的新前沿。

Current opinion in HIV and AIDS Pub Date : 2024-09-01 Epub Date: 2024-06-13 DOI:10.1097/COH.0000000000000864
Rene Bulnes, Netanya S Utay
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引用次数: 0

摘要

综述的目的:菌群失调可能是全身炎症的主要驱动因素,而全身炎症会增加艾滋病病毒感染者(PLWH)发生非艾滋病事件的风险。调节微生物群以逆转这种菌群失调可能是减少炎症的一种新方法,从而降低艾滋病病毒感染者的发病率和死亡率:最近的研究结果:粪便微生物群移植(FMT)、益生菌、益生元、合成益生菌、后益生菌和饮食调整都有可能调节微生物群。迄今为止,这些干预措施在临床试验中的耐受性良好。然而,这些干预措施并未使微生物组发生持续或持久的变化,也未使肠道通透性、微生物转运、炎症、免疫激活或 CD4+ T 细胞计数等生物标志物发生持续变化。摘要:需要进行有充分支持的随机对照试验,以阐明是否可以实现微生物组调节并对 PLWH 的全身炎症产生影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Therapeutic microbiome modulation: new frontiers in HIV treatment.

Purpose of review: Dysbiosis may be a key driver of systemic inflammation, which increases the risk of non-AIDS events in people living with HIV (PLWH). Modulation of the microbiome to reverse this dysbiosis may be a novel approach to decrease inflammation and therefore morbidity and mortality in PLWH.

Recent findings: Fecal microbiota transplantation (FMT), probiotics, prebiotics, synbiotics, postbiotics, and dietary modifications have the potential to modulate the microbiome. These interventions have been well tolerated in clinical trials to date. However, these interventions have not resulted in consistent or lasting changes to the microbiome or consistent changes in biomarkers of intestinal permeability, microbial translocation, inflammation, immune activation, or CD4 + T cell counts. Sustained engraftment may require prebiotics and/or dietary modifications added to either probiotics or FMT.

Summary: Adequately powered randomized controlled trials are needed to elucidate whether microbiome modulation can be achieved and impact systemic inflammation in PLWH.

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