香草气味对早产新生儿缺氧相关周期性呼吸的影响：试点研究。

IF 1.3 4区医学 Q3 PEDIATRICS

Archives De Pediatrie Pub Date : 2024-08-01 DOI:10.1016/j.arcped.2024.03.002

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引用次数: 0

摘要

背景：与周期性呼吸（PB）相关的间歇性缺氧会对早产儿造成长期的有害影响。使用香草气味进行嗅觉刺激对出生后几天/几周内的早产儿呼吸暂停有好处。我们的目的是首次确定香草味是否也能减少与早产儿呼吸暂停相关的间歇性缺氧：本试验研究是一项平衡交叉临床试验，包括 27 名妊娠 30 到 33+6 周之间出生的早产儿。我们在相隔 24 小时的两个晚上进行了 12 小时的记录。所有婴儿在第一个或第二个研究夜随机接触香草气味。主要结果是不饱和指数，即每小时脉搏血氧饱和度（SpO2）值的数量：总体而言，接触香草气味并不会明显降低失饱和指数（干预之夜为 52 ± 22 次/小时 [平均值 ± SD] 与 57 ± 26 次/小时，P = 0.2）；此外，也不会明显改变任何次要结果。不过，在初步的事后分组分析中，香草气味对饱和度指数≥70/h的婴儿的影响具有统计学意义（从86 ± 12降至65 ± 23，p = 0.04）：在这项试验性研究中，香草气味总体上并不能降低妊娠 30-33+6 周（即接近足月时出生）婴儿与 PB 相关的间歇性缺氧。不过，初步结果表明，香草味对脱饱和指数最高的婴儿有好处，因此有必要对存在与 PB 相关的间歇性缺氧的婴儿以及早产儿进行进一步研究。

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Effects of vanilla odor on hypoxia-related periodic breathing in premature newborns: A pilot study

Background

Periodic breathing (PB)-related intermittent hypoxia can have long-lasting deleterious consequences in preterm infants. Olfactory stimulation using vanilla odor is beneficial for apnea of prematurity in the first postnatal days/weeks. We aimed to determine for the first time whether vanilla odor can also decrease PB-related intermittent hypoxia.

Method

This pilot study was a balanced crossover clinical trial including 27 premature infants born between 30 and 33⁺⁶ weeks of gestation. We performed 12-h recordings on two nights separated by a 24-h period. All infants were randomly exposed to vanilla odor on the first or second study night. The primary outcome was the desaturation index, defined as the number per hour of pulse oximetry (SpO₂) values <90 % for at least 5 s, together with a drop of ≥5 % from the preceding value. Univariate mixed linear models were used for the statistical analysis.

Results

Overall, exposure to vanilla odor did not significantly decrease the desaturation index (52 ± 22 events/h [mean ± SD] on the intervention night vs. 57 ± 26, p = 0.2); furthermore, it did not significantly alter any secondary outcome. In a preliminary post hoc subgroup analysis, however, the effect of vanilla odor was statistically significant in infants with a desaturation index of ≥70/h (from 86 ± 12 to 65 ± 23, p = 0.04).

Conclusion

In this pilot study, vanilla odor overall did not decrease PB-related intermittent hypoxia in infants born at 30–33⁺⁶ weeks of gestation, which is when they are close to term. Preliminary results suggesting a beneficial effect in infants with the highest desaturation index, however, justify further studies in the presence of PB-related intermittent hypoxia as well as in infants born more prematurely.

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来源期刊

Archives De Pediatrie 医学-小儿科

CiteScore

2.80

自引率

5.60%

发文量

106

审稿时长

24.1 weeks

期刊介绍： Archives de Pédiatrie publishes in English original Research papers, Review articles, Short communications, Practice guidelines, Editorials and Letters in all fields relevant to pediatrics. Eight issues of Archives de Pédiatrie are released annually, as well as supplementary and special editions to complete these regular issues. All manuscripts submitted to the journal are subjected to peer review by international experts, and must: Be written in excellent English, clear and easy to understand, precise and concise; Bring new, interesting, valid information - and improve clinical care or guide future research; Be solely the work of the author(s) stated; Not have been previously published elsewhere and not be under consideration by another journal; Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. Archives de Pédiatrie is the official publication of the French Society of Pediatrics.