阐明 Mir-23-27-24 簇如何调控发育和衰老。

IF 9.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Xin Le Yap, Jun-An Chen
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引用次数: 0

摘要

微小核糖核酸(miRNA)是基因表达的关键调控因子,参与了从早期发育阶段到复杂衰老过程的生物过程。广泛的研究强调了 miRNA 在协调真核生物发育过程中的基本作用,miRNA 生物发生紊乱会导致早期死亡。此外,miRNA 功能的紊乱也与衰老过程有关,特别是在线虫和苍蝇等模式生物中。miRNA 在脊椎动物基因组中往往是成簇的,通过聚集在单个转录本中精细地调节一系列生物通路。虽然对它们在发育过程中的作用进行了广泛的研究,但 miRNA 簇在调控衰老过程中的潜在影响在很大程度上仍不清楚。在这篇综述中,我们以 Mir-23-27-24 集群为范例,揭示了 miRNA 集群在胚胎发育过程中的细微生理功能,并探讨了它们在衰老过程中的潜在参与。此外,我们主张进一步研究 miRNA 簇(尤其是 Mir-23-27-24 簇)之间错综复杂的相互作用,以塑造衰老的调控格局。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Elucidation of how the Mir-23-27-24 cluster regulates development and aging

Elucidation of how the Mir-23-27-24 cluster regulates development and aging

Elucidation of how the Mir-23-27-24 cluster regulates development and aging
MicroRNAs (miRNAs) are pivotal regulators of gene expression and are involved in biological processes spanning from early developmental stages to the intricate process of aging. Extensive research has underscored the fundamental role of miRNAs in orchestrating eukaryotic development, with disruptions in miRNA biogenesis resulting in early lethality. Moreover, perturbations in miRNA function have been implicated in the aging process, particularly in model organisms such as nematodes and flies. miRNAs tend to be clustered in vertebrate genomes, finely modulating an array of biological pathways through clustering within a single transcript. Although extensive research of their developmental roles has been conducted, the potential implications of miRNA clusters in regulating aging remain largely unclear. In this review, we use the Mir-23-27-24 cluster as a paradigm, shedding light on the nuanced physiological functions of miRNA clusters during embryonic development and exploring their potential involvement in the aging process. Moreover, we advocate further research into the intricate interplay among miRNA clusters, particularly the Mir-23-27-24 cluster, in shaping the regulatory landscape of aging. MicroRNAs significantly influence everything from growth to aging. However, the specific roles of certain miRNA clusters, like Mir-23-27-24, in aging are less understood. This review investigates the Mir-23-27-24 cluster’s function in embryonic growth and possible aging regulation. It’s a comprehensive review of how the Mir-23-27-24 cluster affects vital biological processes and aging, combining existing research to fill knowledge gaps. The Mir-23-27-24 cluster includes miRNAs vital in development stages and linked to various diseases, including cancer. Researchers underline the cluster’s role in embryonic development and its overlooked role in aging. They explore how these miRNAs control gene expression and contribute to the complexity of biological functions. This study implies that miRNA clusters like Mir-23-27-24 could be crucial in aging, opening new paths for aging research and potential treatments for age-related diseases. This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.
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来源期刊
Experimental and Molecular Medicine
Experimental and Molecular Medicine 医学-生化与分子生物学
CiteScore
19.50
自引率
0.80%
发文量
166
审稿时长
3 months
期刊介绍: Experimental & Molecular Medicine (EMM) stands as Korea's pioneering biochemistry journal, established in 1964 and rejuvenated in 1996 as an Open Access, fully peer-reviewed international journal. Dedicated to advancing translational research and showcasing recent breakthroughs in the biomedical realm, EMM invites submissions encompassing genetic, molecular, and cellular studies of human physiology and diseases. Emphasizing the correlation between experimental and translational research and enhanced clinical benefits, the journal actively encourages contributions employing specific molecular tools. Welcoming studies that bridge basic discoveries with clinical relevance, alongside articles demonstrating clear in vivo significance and novelty, Experimental & Molecular Medicine proudly serves as an open-access, online-only repository of cutting-edge medical research.
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