体液生物标志物揭示了病理衰老的特征。

IF 2.7 3区医学 Q2 CLINICAL NEUROLOGY

Seizure-European Journal of Epilepsy Pub Date : 2025-05-01 DOI:10.1016/j.seizure.2024.05.019

Niels Hansen , Jens Wiltfang

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引用次数: 0

摘要

衰老是大脑中一个多层面、变化多端的过程。识别衰老生物标志物是区分病理性衰老和生理性衰老的一种手段。本综述旨在重点介绍液体生物标志物领域的两项新进展，并提请人们注意这一用于早期检测潜在脑部病变的绝佳工具，这些病变会延缓、改变或使生理性衰老转变为病理性衰老。病理性衰老会降低特定疾病（如晚发性癫痫）的发病门槛。体液生物标志物可以在早期阶段揭示病理水平，从而显示在症状出现之前就已经开始的大脑疾病过程；因此，它们与生理性衰老不同。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Fluid biomarkers unveil signatures of pathological aging

Aging is a multifaceted and highly varied process in the brain. Identifying aging biomarkers is one means of distinguishing pathological from physiological aging. The aim of this narrative review is to focus on two new developments in the field of fluid biomarkers and draw attention to this excellent tool for the early detection of potential brain pathologies that delay, alter, or enable physiological aging to become pathological. Pathological aging can lower the threshold for the development of specific diseases such as late-onset epilepsy. Fluid biomarkers can reveal pathological levels at an early stage and thus indicate disease processes in the brain that begin before symptoms develop; they thus differ from physiological aging.

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来源期刊

Seizure-European Journal of Epilepsy 医学-临床神经学

CiteScore

5.60

自引率

6.70%

发文量

231

审稿时长

34 days

期刊介绍： Seizure - European Journal of Epilepsy is an international journal owned by Epilepsy Action (the largest member led epilepsy organisation in the UK). It provides a forum for papers on all topics related to epilepsy and seizure disorders.