硬脑膜替代物的仿生和非仿生方法:机械性能的影响。

IF 5.1 2区 医学 Q2 CELL & TISSUE ENGINEERING
Nathália Oderich Muniz, Timothée Baudequin
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引用次数: 0

摘要

硬脑膜是脑膜中最远和最坚固的一层,对保护大脑和脊髓至关重要。它的生物力学行为至关重要,因为任何改变都会损害生物功能。近几十年来,由于需要对硬脑膜缺损进行气密性闭合,人们对硬脑膜的兴趣与日俱增,促使了多种替代品的开发。基于胶原蛋白的硬脑膜替代物是常见的商业选择,但它们缺乏原生硬脑膜的复杂生物和结构元素,影响了再生,并可能导致伤口/术后感染和脑脊液漏等并发症。面对这一问题,最近的组织工程学方法侧重于创造生物仿真硬脑膜替代物。本综述旨在讨论在开发有效的硬脑膜替代物时,是模仿原生组织的机械特性更重要,还是确保高生物相容性和生物活性更重要,或者这两个方面是否应系统地联系起来。在简要介绍了原生颅骨硬脑膜的特性和结构后,我们描述了生物仿真硬脑膜替代物的优势和局限性,以便更好地理解它们的相关性。我们特别考虑了生物力学特性对硬脑膜修复效果的影响。最后,我们探讨了开发理想硬脑膜替代物的障碍和前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biomimetic and Nonbiomimetic Approaches in Dura Substitutes: The Influence of Mechanical Properties.

The dura mater, the furthest and strongest layer of the meninges, is crucial for protecting the brain and spinal cord. Its biomechanical behavior is vital, as any alterations can compromise biological functions. In recent decades, interest in the dura mater has increased due to the need for hermetic closure of dural defects prompting the development of several substitutes. Collagen-based dural substitutes are common commercial options, but they lack the complex biological and structural elements of the native dura mater, impacting regeneration and potentially causing complications like wound/postoperative infection and cerebrospinal fluid (CSF) leakage. To face this issue, recent tissue engineering approaches focus on creating biomimetic dura mater substitutes. The objective of this review is to discuss whether mimicking the mechanical properties of native tissue or ensuring high biocompatibility and bioactivity is more critical in developing effective dural substitutes, or if both aspects should be systematically linked. After a brief description of the properties and architecture of the native cranial dura, we describe the advantages and limitations of biomimetic dura mater substitutes to better understand their relevance. In particular, we consider biomechanical properties' impact on dura repair's effectiveness. Finally, the obstacles and perspectives for developing the ideal dural substitute are explored.

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来源期刊
Tissue Engineering. Part B, Reviews
Tissue Engineering. Part B, Reviews Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
12.80
自引率
1.60%
发文量
150
期刊介绍: Tissue Engineering Reviews (Part B) meets the urgent need for high-quality review articles by presenting critical literature overviews and systematic summaries of research within the field to assess the current standing and future directions within relevant areas and technologies. Part B publishes bi-monthly.
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