1 型嗜睡症患者夜间睡眠结构的改变与焦虑、抑郁和疲劳程度的升高。

IF 3 2区 医学 Q2 CLINICAL NEUROLOGY
Nature and Science of Sleep Pub Date : 2024-06-08 eCollection Date: 2024-01-01 DOI:10.2147/NSS.S452665
Jieyang Yu, Yanan Zhang, Lijia Cai, Qingqing Sun, Wanru Li, Junfang Zhou, Jianmin Liang, Zan Wang
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引用次数: 0

摘要

目的:本研究旨在评估1型嗜睡症(NT1)患者的夜间睡眠结构以及焦虑、抑郁和疲劳程度:方法:研究人员招募了 30 名 1 型嗜睡症患者和 35 名健康对照者,并使用埃普沃思嗜睡量表(ESS)、广泛性焦虑症-7、患者健康问卷-9、疲劳严重程度量表(FSS)、多导睡眠图、多重睡眠潜伏期测试和脑功能状态监测进行评估。统计分析使用 SPSS Statistics for Windows 23.0 版本进行。采用本杰明-霍奇伯格校正法控制假发现率:除了典型的临床表现外,NT1患者还容易出现夜间睡眠障碍、焦虑、抑郁和疲劳等合并症。与对照组相比,NT1患者的睡眠结构异常,包括总睡眠时间增加(P adj=0.007)、睡眠效率降低(P adj=0.002)、睡眠开始潜伏期缩短(P adjP adj=0.002)、N1%增加(P adj=0.006)、N2%、N3%和REM%降低(P adj=0.007、P adjP adj=0.013)。37%的患者患有中重度阻塞性睡眠呼吸暂停-低通气综合征。60%的患者有复杂的快速眼动睡眠,但无失张力。在脑功能状态监测中,NT1 患者的焦虑倾向增加(P adjP adj=0.020)。FSS评分与脑疲劳呈正相关(P adjP adj=0.013,P adj=0.029)。此外,ESS评分和脑疲劳在治疗3个月后有所下降(P=0.012,P=0.030):结论:NT1 患者夜间睡眠结构异常,表现出焦虑、抑郁和疲劳。盐酸哌醋甲酯缓释片联合文拉法辛治疗3个月后,白天过度嗜睡和疲劳症状有所改善。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Changed Nocturnal Sleep Structure and Higher Anxiety, Depression, and Fatigue in Patients with Narcolepsy Type 1.

Purpose: This study aimed to evaluate nocturnal sleep structure and anxiety, depression, and fatigue in patients with narcolepsy type 1 (NT1).

Methods: Thirty NT1 patients and thirty-five healthy controls were enrolled and evaluated using the Epworth sleepiness scale (ESS), Generalized Anxiety Disorder-7, Patient Health Questionnaire-9, Fatigue Severity Scale (FSS), polysomnography, multiple sleep latency test, and brain function state monitoring. Statistical analyses were performed using SPSS Statistics for Windows, version 23.0. Benjamini-Hochberg correction was performed to control the false discovery rate.

Results: Apart from typical clinical manifestations, patients with NT1 are prone to comorbidities such as nocturnal sleep disorders, anxiety, depression, and fatigue. Compared with the control group, patients with NT1 exhibited abnormal sleep structure, including increased total sleep time (P adj=0.007), decreased sleep efficiency (P adj=0.002), shortening of sleep onset latency (P adj<0.001), elevated wake after sleep onset (P adj=0.002), increased N1% (P adj=0.006), and reduced N2%, N3%, and REM% (P adj=0.007, P adj<0.001, P adj=0.013). Thirty-seven percent of patients had moderate to severe obstructive sleep apnea-hypopnea syndrome. And sixty percent of patients were complicated with REM sleep without atonia. Patients with NT1 displayed increased anxiety propensity (P adj<0.001), and increased brain fatigue (P adj=0.020) in brain function state monitoring. FSS scores were positively correlated with brain fatigue (P adj<0.001) and mean sleep latency was inversely correlated with FSS scores and brain fatigue (P adj=0.013, P adj=0.029). Additionally, ESS scores and brain fatigue decreased after 3 months of therapy (P=0.012, P=0.030).

Conclusion: NT1 patients had abnormal nocturnal sleep structures, who showed increased anxiety, depression, and fatigue. Excessive daytime sleepiness and fatigue improved after 3 months of treatment with methylphenidate hydrochloride prolonged-release tablets in combination with venlafaxine.

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来源期刊
Nature and Science of Sleep
Nature and Science of Sleep Neuroscience-Behavioral Neuroscience
CiteScore
5.70
自引率
5.90%
发文量
245
审稿时长
16 weeks
期刊介绍: Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep. Specific topics covered in the journal include: The functions of sleep in humans and other animals Physiological and neurophysiological changes with sleep The genetics of sleep and sleep differences The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness Sleep changes with development and with age Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause) The science and nature of dreams Sleep disorders Impact of sleep and sleep disorders on health, daytime function and quality of life Sleep problems secondary to clinical disorders Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health) The microbiome and sleep Chronotherapy Impact of circadian rhythms on sleep, physiology, cognition and health Mechanisms controlling circadian rhythms, centrally and peripherally Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms Epigenetic markers of sleep or circadian disruption.
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