一项针对加拿大儿童的全国横断面研究显示，小儿肥胖症、化学混合物和环境因素之间存在关联。

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2024-06-14 DOI:10.1111/ijpo.13117

Rose Dugandzic, Natalia Konstantelos, Yamei Yu, Eric Lavigne, Sebastian Srugo, Justin J. Lang, Kristian Larsen, Tyler Pollock, Paul Villeneuve, Errol M. Thomson, Miranda MacPherson, Robert Dales, Sabit Cakmak

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引用次数: 0

摘要

背景：虽然人们怀疑单一化学物质的暴露会导致肥胖，但对化学混合物在儿童肥胖中的综合作用却不甚了解：我们的目的是在加拿大儿童人群样本中评估化学混合物与肥胖之间的潜在关联：我们从 2007 年至 2019 年的加拿大健康措施横断面调查中确定了 3-11 岁儿童的生物监测和健康数据。对血液或尿液中的几种相关化学物质进行了测量，并根据测量的人体测量数据对小儿肥胖进行了定义。利用基于量子的 G 计算分析，我们量化了事先选定的三种化学混合物的影响。根据有向无环图确定的社会人口和环境因素对模型进行了调整。结果通过调整后的相对风险 (RR) 和 95% 置信区间 (95% CI) 显示：我们纳入了 9147 名儿童。其中，24.1%的儿童超重或肥胖。接触双酚 A、丙烯酰胺、缩水甘油醚、金属、对羟基苯甲酸酯和砷的混合物会使儿童超重或肥胖的风险增加 45% (95% CI 1.09, 1.93)，肥胖的风险增加 109% (95% CI 1.27, 3.42)，中心性肥胖的风险增加 82% (95% CI 1.30, 2.56)：我们的研究结果表明，儿童早期接触化学品会导致儿童肥胖，而且化学品可能会产生综合影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Associations between paediatric obesity, chemical mixtures and environmental factors, in a national cross-sectional study of Canadian children

查看原文本刊更多论文

Associations between paediatric obesity, chemical mixtures and environmental factors, in a national cross-sectional study of Canadian children

Background

Whilst single chemical exposures are suspected to be obesogenic, the combined role of chemical mixtures in paediatric obesity is not well understood.

Objectives

We aimed to evaluate the potential associations between chemical mixtures and obesity in a population-based sample of Canadian children.

Methods

We ascertained biomonitoring and health data for children aged 3–11 from the cross-sectional Canadian Health Measures Survey from 2007 to 2019. Several chemicals of interest were measured in blood or urine and paediatric obesity was defined based on measured anthropometrics. Using quantile-based G computational analysis, we quantified the effects of three chemical mixtures selected a priori. Models were adjusted for sociodemographic and environmental factors identified through a directed acyclic graph. Results are presented through adjusted relative risks (RR) with 95% confidence intervals (95% CI).

Results

We included 9147 children. Of these, 24.1% were overweight or obese. Exposure to the mixture of bisphenol A, acrylamide, glycidamide, metals, parabens and arsenic increased the risk of childhood overweight or obesity by 45% (95% CI 1.09, 1.93), obesity by 109% (95% CI 1.27, 3.42) and central obesity by 82% (95% CI 1.30, 2.56).

Conclusions

Our findings support the role of early childhood chemical exposures in paediatric obesity and the potential combined effects of chemicals.

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.