对感染 RSV 的婴儿进行纵向体液分析,确定预先存在的 RSV 株系特异性 G 抗体和不断演变的交叉反应 F 抗体

IF 25.5 1区 医学 Q1 IMMUNOLOGY
Nadège Nziza, Wonyeong Jung, Maanasa Mendu, Tina Chen, Boris Julg, Barney Graham, Octavio Ramilo, Asuncion Mejias, Galit Alter
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引用次数: 0

摘要

呼吸道合胞病毒(RSV)是导致婴儿下呼吸道感染(LRTI)和住院治疗的最常见原因之一。然而,人们对婴儿的免疫控制机制仍不甚了解。对患有轻度(门诊病人)或重度(住院病人)RSV 疾病的 2 岁以下儿童进行的附着蛋白(G)和融合蛋白(F)抗体分析表明,RSV 特异性免疫力存在很大的年龄差异。出生后的头 3 个月可以检测到母体抗体,3 到 6 个月之间会出现较长的免疫脆弱期,6 个月后 FcγR 招募免疫会迅速发展。与健康对照组相比,急性病住院儿童的 G 特异性抗体较低。随着疾病的缓解,RSV 感染婴儿产生了广泛的功能性 RSV 株系特异性 G 反应,并进化出了交叉反应性 F 反应,母体印记极小。这些数据表明,RSV G 特异性功能性体液保护与年龄无关,随着疾病的缓解,RSV F 特异性功能性免疫也会发生演变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Longitudinal humoral analysis in RSV-infected infants identifies pre-existing RSV strain-specific G and evolving cross-reactive F antibodies

Longitudinal humoral analysis in RSV-infected infants identifies pre-existing RSV strain-specific G and evolving cross-reactive F antibodies

Respiratory syncytial virus (RSV) is among the most common causes of lower respiratory tract infection (LRTI) and hospitalization in infants. However, the mechanisms of immune control in infants remain incompletely understood. Antibody profiling against attachment (G) and fusion (F) proteins in children less than 2 years of age, with mild (outpatients) or severe (inpatients) RSV disease, indicated substantial age-dependent differences in RSV-specific immunity. Maternal antibodies were detectable for the first 3 months of life, followed by a long window of immune vulnerability between 3 and 6 months and a rapid evolution of FcγR-recruiting immunity after 6 months of age. Acutely ill hospitalized children exhibited lower G-specific antibodies compared with healthy controls. With disease resolution, RSV-infected infants generated broad functional RSV strain-specific G-responses and evolved cross-reactive F-responses, with minimal maternal imprinting. These data suggest an age-independent RSV G-specific functional humoral correlate of protection, and the evolution of RSV F-specific functional immunity with disease resolution.

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来源期刊
Immunity
Immunity 医学-免疫学
CiteScore
49.40
自引率
2.20%
发文量
205
审稿时长
6 months
期刊介绍: Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.
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