猫科动物糖尿病的胰岛素疗法--研究现状综述

IF 1.9 2区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Nina Haller , Thomas A. Lutz
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引用次数: 0

摘要

肠道摄入营养物质后,增量素激素会增强葡萄糖诱导的胰岛素分泌。特征最明显的增量素激素是胰高血糖素样肽-1(GLP-1)和葡萄糖依赖性促胰岛素多肽(GIP),它们在肠道中产生并随着营养摄入从肠道分泌。增量素只有在血糖水平升高时才会增强内源性胰岛素分泌,因此是治疗 2 型糖尿病的有效药物,其安全性优于外源性胰岛素。虽然增量素疗法(尤其是 GLP-1 激动剂,以及最近的 GLP-1 / GIP 双激动剂和其他影响增量素代谢的药物(如二肽基肽酶-4 (DPP-4) 抑制剂))已被广泛用于人类 2 型糖尿病的治疗,但这些药物尚未被批准用于猫科动物糖尿病的治疗。本综述介绍了胰岛素类药物和猫科动物糖尿病的总体情况,并总结了目前将胰岛素类药物作为猫科动物糖尿病治疗药物的研究情况,以评估其在猫科动物医学中的未来潜力。迄今为止,在健康猫体内使用 GLP-1 受体激动剂(GLP-1RA)的研究在很大程度上证实了它们在其他物种中已知的促胰岛素作用。在糖尿病猫中,GLP-1RA 似乎能显著降低血糖变异性(GV,血糖控制质量的指标),这对疾病管理和预防长期并发症非常重要。然而,要想在猫科动物糖尿病中广泛使用,还需要进行更多的研究,包括对更多的糖尿病猫进行研究,并考虑和测试对超重猫和糖尿病猫进行剂量调整的可能性。此外,还需要对 GLP-1RA 单一疗法的效果进行评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Incretin therapy in feline diabetes mellitus – A review of the current state of research

Incretin hormones potentiate the glucose-induced insulin secretion following enteral nutrient intake. The best characterised incretin hormones are glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) which are produced in and secreted from the gut in response to nutrient ingestion. The property of incretins to enhance endogenous insulin secretion only at elevated blood glucose levels makes them interesting therapeutics for type 2 diabetes mellitus with a better safety profile than exogenous insulin. While incretin therapeutics (especially GLP-1 agonists, and more recently also GLP-1 / GIP dual agonists and other drugs that influence the incretin metabolism (e.g., dipeptidyl peptidase-4 (DPP-4) inhibitors)) are already widely used treatment options for human type 2 diabetes, these drugs are not yet approved for the therapy of feline diabetes mellitus. This review provides an introduction to incretins and feline diabetes mellitus in general and summarises the current study situation on incretins as therapeutics for feline diabetes mellitus to assess their possible future potential in feline medicine. Studies to date on the use of GLP-1 receptor agonists (GLP-1RA) in healthy cats largely confirm their insulinotropic effect known from other species. In diabetic cats, GLP-1RAs appear to significantly reduce glycaemic variability (GV, an indicator for the quality of glycaemic control), which is important for the management of the disease and prevention of long-term complications. However, for widespread use in feline diabetes mellitus, further studies are required that include larger numbers of diabetic cats, and that consider and test a possible need for dose adjustments to overweight and diabetic cats. Also evaluation of the outcome of GLP-1RA monotherapy will be neceessary.

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来源期刊
Domestic animal endocrinology
Domestic animal endocrinology 农林科学-奶制品与动物科学
CiteScore
5.50
自引率
4.80%
发文量
58
审稿时长
31 days
期刊介绍: Domestic Animal Endocrinology publishes scientific papers dealing with the study of the endocrine physiology of domestic animal species. Those manuscripts utilizing other species as models for clinical or production problems associated with domestic animals are also welcome. Topics covered include: Classical and reproductive endocrinology- Clinical and applied endocrinology- Regulation of hormone secretion- Hormone action- Molecular biology- Cytokines- Growth factors
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