Nikolaos Mouchtouris , Isaiah Ailes , Ki Chang , Adam Flanders , Feroze Mohamed , Stavropoula Tjoumakaris , Reid Gooch , Pascal Jabbour , Robert Rosenwasser , Mahdi Alizadeh
{"title":"机械血栓切除术对急性缺血性脑卒中患者血脑屏障的影响：使用 DP-pCASL 和 NODDI 进行的非对比 MR 成像研究。","authors":"Nikolaos Mouchtouris , Isaiah Ailes , Ki Chang , Adam Flanders , Feroze Mohamed , Stavropoula Tjoumakaris , Reid Gooch , Pascal Jabbour , Robert Rosenwasser , Mahdi Alizadeh","doi":"10.1016/j.nicl.2024.103629","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and purpose</h3><p>While mechanical thrombectomy (MT) achieves restoration of cerebral blood flow to the area at risk in patients with acute ischemic stroke (AIS), the influx of blood flow may exacerbate the blood–brain barrier (BBB) disruption and extravasation across the BBB, and it therefore remains unclear how reperfusion impacts the blood–brain barrier integrity. In this study, we use diffusion-prepared pseudocontinuous ASL (DP-pCASL) and Neurite Orientation Dispersion and Density Imaging (NODDI) sequence to measure the water exchange rate (k<sub>w</sub>) in patients who underwent either MT or medical management and determine its impact on the brain tissue microstructure in order to elucidate the impact of MT on BBB complex integrity.</p></div><div><h3>Materials and methods</h3><p>We prospectively enrolled 21 patients with AIS treated at our institution from 10/2021 to 6/2023 who underwent MR imaging at a 3.0-Tesla scanner. Patients underwent DP-pCASl and NODDI imaging in addition to the standard stroke protocol which generated cerebral blood flow (CBF), arterial transit time (ATT), water exchange rate (k<sub>w</sub>), orientation dispersion index (ODI), intracellular volume fraction (ICVF), and free water fraction (FWF) parametric maps.</p></div><div><h3>Results</h3><p>Of the 21 patients, 11 underwent MT and 10 were treated non-operatively. The average age and NIHSS for the MT cohort and non-MT cohorts were 69.3 ± 16.6 years old and 15.0 (12.0–20.0), and 70.2 ± 10.7 (p = 0.882) and 6.0 (3.8–9.0, p = 0.003) respectively. The average CBF, ATT, and k<sub>w</sub> in the infarcted territory of the MT cohort were 38.2 (18.4–59.6), 1347.6 (1182.5–1842.3), and 107.8 (79.2–140.1) respectively. The average CBF, ATT, and k<sub>w</sub> in the stroke ROI were 16.0 (8.8–36.6, p = 0.036), 1090.8 (937.1–1258.9, p = 0.013), 89.7 (68.0–122.7, p = 0.314) respectively. Linear regression analysis showed increasing CBF (p = 0.008) and undergoing mechanical thrombectomy (p = 0.048) were significant predictors of increased k<sub>w</sub>.</p></div><div><h3>Conclusion</h3><p>Using our multimodal non-contrast MRI protocol, we demonstrate that increased CBF and mechanical thrombectomy increased k<sub>w</sub>, suggesting a better functioning BBB complex. Higher k<sub>w</sub> suggests less disruption of the BBB complex in the MT cohort.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224000688/pdfft?md5=0d134a24a27460382f12f191ffa1a580&pid=1-s2.0-S2213158224000688-main.pdf","citationCount":"0","resultStr":"{\"title\":\"The impact of mechanical thrombectomy on the blood–brain barrier in patients with acute ischemic stroke: A non-contrast MR imaging study using DP-pCASL and NODDI\",\"authors\":\"Nikolaos Mouchtouris , Isaiah Ailes , Ki Chang , Adam Flanders , Feroze Mohamed , Stavropoula Tjoumakaris , Reid Gooch , Pascal Jabbour , Robert Rosenwasser , Mahdi Alizadeh\",\"doi\":\"10.1016/j.nicl.2024.103629\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background and purpose</h3><p>While mechanical thrombectomy (MT) achieves restoration of cerebral blood flow to the area at risk in patients with acute ischemic stroke (AIS), the influx of blood flow may exacerbate the blood–brain barrier (BBB) disruption and extravasation across the BBB, and it therefore remains unclear how reperfusion impacts the blood–brain barrier integrity. In this study, we use diffusion-prepared pseudocontinuous ASL (DP-pCASL) and Neurite Orientation Dispersion and Density Imaging (NODDI) sequence to measure the water exchange rate (k<sub>w</sub>) in patients who underwent either MT or medical management and determine its impact on the brain tissue microstructure in order to elucidate the impact of MT on BBB complex integrity.</p></div><div><h3>Materials and methods</h3><p>We prospectively enrolled 21 patients with AIS treated at our institution from 10/2021 to 6/2023 who underwent MR imaging at a 3.0-Tesla scanner. Patients underwent DP-pCASl and NODDI imaging in addition to the standard stroke protocol which generated cerebral blood flow (CBF), arterial transit time (ATT), water exchange rate (k<sub>w</sub>), orientation dispersion index (ODI), intracellular volume fraction (ICVF), and free water fraction (FWF) parametric maps.</p></div><div><h3>Results</h3><p>Of the 21 patients, 11 underwent MT and 10 were treated non-operatively. The average age and NIHSS for the MT cohort and non-MT cohorts were 69.3 ± 16.6 years old and 15.0 (12.0–20.0), and 70.2 ± 10.7 (p = 0.882) and 6.0 (3.8–9.0, p = 0.003) respectively. The average CBF, ATT, and k<sub>w</sub> in the infarcted territory of the MT cohort were 38.2 (18.4–59.6), 1347.6 (1182.5–1842.3), and 107.8 (79.2–140.1) respectively. The average CBF, ATT, and k<sub>w</sub> in the stroke ROI were 16.0 (8.8–36.6, p = 0.036), 1090.8 (937.1–1258.9, p = 0.013), 89.7 (68.0–122.7, p = 0.314) respectively. Linear regression analysis showed increasing CBF (p = 0.008) and undergoing mechanical thrombectomy (p = 0.048) were significant predictors of increased k<sub>w</sub>.</p></div><div><h3>Conclusion</h3><p>Using our multimodal non-contrast MRI protocol, we demonstrate that increased CBF and mechanical thrombectomy increased k<sub>w</sub>, suggesting a better functioning BBB complex. Higher k<sub>w</sub> suggests less disruption of the BBB complex in the MT cohort.</p></div>\",\"PeriodicalId\":54359,\"journal\":{\"name\":\"Neuroimage-Clinical\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2213158224000688/pdfft?md5=0d134a24a27460382f12f191ffa1a580&pid=1-s2.0-S2213158224000688-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuroimage-Clinical\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2213158224000688\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROIMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroimage-Clinical","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213158224000688","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROIMAGING","Score":null,"Total":0}
The impact of mechanical thrombectomy on the blood–brain barrier in patients with acute ischemic stroke: A non-contrast MR imaging study using DP-pCASL and NODDI
Background and purpose
While mechanical thrombectomy (MT) achieves restoration of cerebral blood flow to the area at risk in patients with acute ischemic stroke (AIS), the influx of blood flow may exacerbate the blood–brain barrier (BBB) disruption and extravasation across the BBB, and it therefore remains unclear how reperfusion impacts the blood–brain barrier integrity. In this study, we use diffusion-prepared pseudocontinuous ASL (DP-pCASL) and Neurite Orientation Dispersion and Density Imaging (NODDI) sequence to measure the water exchange rate (kw) in patients who underwent either MT or medical management and determine its impact on the brain tissue microstructure in order to elucidate the impact of MT on BBB complex integrity.
Materials and methods
We prospectively enrolled 21 patients with AIS treated at our institution from 10/2021 to 6/2023 who underwent MR imaging at a 3.0-Tesla scanner. Patients underwent DP-pCASl and NODDI imaging in addition to the standard stroke protocol which generated cerebral blood flow (CBF), arterial transit time (ATT), water exchange rate (kw), orientation dispersion index (ODI), intracellular volume fraction (ICVF), and free water fraction (FWF) parametric maps.
Results
Of the 21 patients, 11 underwent MT and 10 were treated non-operatively. The average age and NIHSS for the MT cohort and non-MT cohorts were 69.3 ± 16.6 years old and 15.0 (12.0–20.0), and 70.2 ± 10.7 (p = 0.882) and 6.0 (3.8–9.0, p = 0.003) respectively. The average CBF, ATT, and kw in the infarcted territory of the MT cohort were 38.2 (18.4–59.6), 1347.6 (1182.5–1842.3), and 107.8 (79.2–140.1) respectively. The average CBF, ATT, and kw in the stroke ROI were 16.0 (8.8–36.6, p = 0.036), 1090.8 (937.1–1258.9, p = 0.013), 89.7 (68.0–122.7, p = 0.314) respectively. Linear regression analysis showed increasing CBF (p = 0.008) and undergoing mechanical thrombectomy (p = 0.048) were significant predictors of increased kw.
Conclusion
Using our multimodal non-contrast MRI protocol, we demonstrate that increased CBF and mechanical thrombectomy increased kw, suggesting a better functioning BBB complex. Higher kw suggests less disruption of the BBB complex in the MT cohort.
期刊介绍：
NeuroImage: Clinical, a journal of diseases, disorders and syndromes involving the Nervous System, provides a vehicle for communicating important advances in the study of abnormal structure-function relationships of the human nervous system based on imaging.
The focus of NeuroImage: Clinical is on defining changes to the brain associated with primary neurologic and psychiatric diseases and disorders of the nervous system as well as behavioral syndromes and developmental conditions. The main criterion for judging papers is the extent of scientific advancement in the understanding of the pathophysiologic mechanisms of diseases and disorders, in identification of functional models that link clinical signs and symptoms with brain function and in the creation of image based tools applicable to a broad range of clinical needs including diagnosis, monitoring and tracking of illness, predicting therapeutic response and development of new treatments. Papers dealing with structure and function in animal models will also be considered if they reveal mechanisms that can be readily translated to human conditions.
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