机会性病原体表皮葡萄球菌的致病性和毒性。

IF 5.5 1区 农林科学 Q1 IMMUNOLOGY
Virulence Pub Date : 2024-12-01 Epub Date: 2024-06-13 DOI:10.1080/21505594.2024.2359483
Órla Burke, Merve S Zeden, James P O'Gara
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引用次数: 0

摘要

表皮葡萄球菌和其他凝固酶阴性葡萄球菌普遍存在于皮肤和粘膜上,长期以来,这些微生物给医疗机构中易受感染的病人带来的感染风险一直被忽视。在认识到生物膜是表皮葡萄球菌的一个重要毒力决定因素之前,在诊断标本中分离出这种微生物往往被视为临床意义不大,可能会延误诊断和适当的治疗,导致慢性感染和发病率或死亡率上升。虽然我们对这种重要机会性病原体的生物膜机制的了解取得了令人瞩目的进展,但对其他毒力决定因素的研究却落后于金黄色葡萄球菌。在这篇综述中,我们探讨了表皮葡萄球菌更广泛的毒力潜能,包括生物膜、毒素、蛋白酶、免疫逃避策略和抗生素耐药机制,以及当前和未来改进治疗干预的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The pathogenicity and virulence of the opportunistic pathogen Staphylococcus epidermidis.

The pervasive presence of Staphylococcus epidermidis and other coagulase-negative staphylococci on the skin and mucous membranes has long underpinned a casual disregard for the infection risk that these organisms pose to vulnerable patients in healthcare settings. Prior to the recognition of biofilm as an important virulence determinant in S. epidermidis, isolation of this microorganism in diagnostic specimens was often overlooked as clinically insignificant with potential delays in diagnosis and onset of appropriate treatment, contributing to the establishment of chronic infection and increased morbidity or mortality. While impressive progress has been made in our understanding of biofilm mechanisms in this important opportunistic pathogen, research into other virulence determinants has lagged S. aureus. In this review, the broader virulence potential of S. epidermidis including biofilm, toxins, proteases, immune evasion strategies and antibiotic resistance mechanisms is surveyed, together with current and future approaches for improved therapeutic interventions.

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来源期刊
Virulence
Virulence IMMUNOLOGY-MICROBIOLOGY
CiteScore
9.20
自引率
1.90%
发文量
123
审稿时长
6-12 weeks
期刊介绍: Virulence is a fully open access peer-reviewed journal. All articles will (if accepted) be available for anyone to read anywhere, at any time immediately on publication. Virulence is the first international peer-reviewed journal of its kind to focus exclusively on microbial pathogenicity, the infection process and host-pathogen interactions. To address the new infectious challenges, emerging infectious agents and antimicrobial resistance, there is a clear need for interdisciplinary research.
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