生殖细胞对脊椎动物体细胞生长和衰老的性别依赖性调控

IF 12.5 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2024-06-12 DOI:10.1126/sciadv.adi1621

Kota Abe, Hikaru Ino, Tomomi Niwa, Daniel Semmy, Ayami Takaochi, Takashi Nishimura, Chihiro Mogi, Maki Uenaka, Masaru Ishii, Kaori Tanaka, Yasuyuki Ohkawa, Tohru Ishitani

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引用次数: 0

摘要

生殖细胞在体细胞生长和衰老中的功能已在无脊椎动物模型中得到证实，但在脊椎动物中仍不清楚。我们在短寿命脊椎动物模型 Nothobranchius furzeri 中证明了生殖细胞对体细胞的性别依赖性调控。在雌性动物中，生殖细胞的移除缩短了寿命，减少了雌激素，增加了胰岛素样生长因子1（IGF-1）信号传导。与此相反，雄性生殖细胞被移除后，维生素 D 信号增加，从而改善了健康状况。雌性和雄性的体型都会增大，但信号途径不同，即雌性和雄性的 IGF-1 和维生素 D 信号途径不同。因此，脊椎动物的生殖细胞根据性别的不同，通过内分泌系统的不同途径调节体细胞的生长和衰老，这可能是生殖策略的性别差异的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Sex-dependent regulation of vertebrate somatic growth and aging by germ cells

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Sex-dependent regulation of vertebrate somatic growth and aging by germ cells

The function of germ cells in somatic growth and aging has been demonstrated in invertebrate models but remains unclear in vertebrates. We demonstrated sex-dependent somatic regulation by germ cells in the short-lived vertebrate model Nothobranchius furzeri. In females, germ cell removal shortened life span, decreased estrogen, and increased insulin-like growth factor 1 (IGF-1) signaling. In contrast, germ cell removal in males improved their health with increased vitamin D signaling. Body size increased in both sexes but was caused by different signaling pathways, i.e., IGF-1 and vitamin D in females and males, respectively. Thus, vertebrate germ cells regulate somatic growth and aging through different pathways of the endocrine system, depending on the sex, which may underlie the sexual difference in reproductive strategies.

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来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.