代谢手术对肝脏硬度影响的系统性回顾和元分析

IF 1.4 Q4 PHARMACOLOGY & PHARMACY

Reviews on recent clinical trials Pub Date : 2024-06-11 DOI:10.2174/0115748871303052240529102003

Tannaz Jamialahmadi, Matthew Kroh, Sorour Ashari, Wael Almahmeed, Ali Jangjoo, Luis E Simental-Mendía, Sepideh Salehabadi, Khalid Al-Rasadi, Amirhossein Sahebkar

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引用次数: 0

摘要

背景：减肥手术是治疗肥胖症和肥胖相关并发症的有效方法之一。除了糖尿病、高血压和高胆固醇血症等与体重相关的并发症外，非酒精性脂肪肝在病态肥胖患者中也很常见。减肥手术是治疗非酒精性脂肪肝的方法之一。因此，本综述侧重于减肥手术对通过剪切波弹性成像测量的肝脏弹性的潜在作用：方法：进行了系统的文献检索，并使用随机效应模型对有关异质性的研究进行了评估：对包括350名参与者在内的6项试验（随访3-12个月）进行的荟萃分析表明，术后肝脏弹性显著降低（WMD：-1.149，95% CI：-1.767，-0.532，p <0.001；I2：81.55%）：减肥手术与肝脏弹性下降有关。结论：减肥手术与肝脏弹性下降有关，这种改善可能与体重减轻或减肥手术的其他机制有关。

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Systematic Review and Meta-analysis of the Impact of Metabolic Surgery on Hepatic Stiffness.

Background: Bariatric surgery is one of the effective therapeutic options for people with obesity and obesity-related co-morbidities. In addition to weight-related co-morbid diseases, including diabetes, hypertension, and hypercholesterolemia, non-alcoholic fatty liver disease (NAFLD) is common in patients with morbid obesity. Bariatric surgery is one of the therapeutic options in the management of NAFLD. Hence, this review focused on the potential role of bariatric surgery on hepatic elasticity measured through shear wave elastography.

Methods: A systematic literature search was performed, and the studies regarding heterogeneity were evaluated using the random-effects model.

Results: The meta-analysis on 6 trials (3-12 months follow-up) including 350 participants showed a significant reduction of liver elasticity after surgery (WMD: -1.149, 95% CI: -1.767, -0.532, p < 0.001; I2:81.55%).

Conclusion: Bariatric surgery is associated with decreased liver elasticity. This improvement could be related to weight loss or other mechanisms of bariatric surgery.

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来源期刊

Reviews on recent clinical trials PHARMACOLOGY & PHARMACY-

CiteScore

3.10

自引率

5.30%

发文量

期刊介绍： Reviews on Recent Clinical Trials publishes frontier reviews on recent clinical trials of major importance. The journal"s aim is to publish the highest quality review articles in the field. Topics covered include: important Phase I – IV clinical trial studies, clinical investigations at all stages of development and therapeutics. The journal is essential reading for all researchers and clinicians involved in drug therapy and clinical trials.