酮饮食对帕金森病症状、生物标志物、抑郁、焦虑和生活质量的影响:一项纵向研究。

IF 2.3 Q3 CLINICAL NEUROLOGY
Neurodegenerative disease management Pub Date : 2024-01-01 Epub Date: 2024-06-13 DOI:10.1080/17582024.2024.2352394
Melanie M Tidman, Dawn Reid White, Tim A White
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引用次数: 0

摘要

目的:有证据表明,低碳水化合物饮食(LCHF)可能有助于治疗帕金森病(PD)等神经退行性疾病;然而,文献中还存在空白。患者与方法:我们开展了一项为期 24 周的小型试点研究,调查 LCHF 饮食对七名帕金森病患者的运动和非运动症状、健康生物标志物、焦虑和抑郁的影响。我们还记录了患者在此过程中的体验(生活质量 [QoL])。研究结果参与者报告说,他们的生物标志物得到了改善,认知能力、情绪、运动和非运动症状得到了增强,疼痛和焦虑有所减轻。参与者认为这些改善提高了他们的生活质量。结论我们得出的结论是,低碳水化合物饮食干预是安全、可行的,而且可能有效缓解这种疾病的症状。不过,还需要进行更广泛的随机对照研究,才能提出具有普遍意义的建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of a keto diet on symptoms of Parkinson's disease, biomarkers, depression, anxiety and quality of life: a longitudinal study.

Aim: Evidence suggests low-carbohydrate diets (LCHF) may assist in treating neurodegenerative diseases such as Parkinson's disease (PD); however, gaps exist in the literature.Patients & methods: We conducted a small 24-week pilot study to investigate the effects of an LCHF diet on motor and nonmotor symptoms, health biomarkers, anxiety, and depression in seven people with PD. We also captured patient experiences during the process (quality of life [QoL]).Results: Participants reported improved biomarkers, enhanced cognition, mood, motor and nonmotor symptoms, and reduced pain and anxiety. Participants felt improvements enhanced their QoL.Conclusion: We conclude that an LCHF intervention is safe, feasible, and potentially effective in mitigating the symptoms of this disorder. However, more extensive randomized controlled studies are needed to create generalizable recommendations.

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来源期刊
CiteScore
4.30
自引率
0.00%
发文量
35
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