突破性入侵霉菌感染的最新进展。

IF 3.6 3区 生物学 Q2 MYCOLOGY
Vera Portillo, Dionysios Neofytos
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引用次数: 0

摘要

突破性霉菌感染(bIMI)的发病率一直在上升,原因是常规使用广谱抗真菌预防药物以及高危患者群体不断增加,尽管诊断和治疗方案取得了进展,但真菌的治疗更具挑战性,导致死亡率居高不下。抗真菌药物的药代动力学、真菌和宿主(包括遗传)因素在 bIMI 的出现中起着重要作用。建议的治疗方法包括改变抗真菌类药物的治疗方法,其中两性霉素-B 类产品作为一线经验性治疗方法占主导地位,从一种广谱唑类药物转换到另一种广谱唑类药物仍然是最常用的治疗方法。未来的展望包括:确定个人对 IMI 的易感性,以量身定制预防和治疗策略;改进诊断测试;以及引入新的抗真菌药物,以降低 bIMI 导致的发病率和死亡率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An Update on Breakthrough Invasive Mold Infections.

The incidence of breakthrough mold infections (bIMI) has been increasing, due to routine administration of broad-spectrum antifungal prophylaxis and an increasing pool of high-risk patient populations, with fungi more challenging to treat, resulting in a sustained high mortality, despite progress in diagnostic and therapeutic options. Pharmacokinetics of antifungal drugs, fungal, and host, including genetic, factors play a role in the emergence of bIMI. Suggested therapeutic approaches have included change of antifungal class treatment, with amphotericin-B products predominating as first-line empirical treatment and switching from one broad-spectrum azole to another remaining the most frequently used treatment modalities. Future perspectives include determining individual susceptibility to IMI to tailor prophylaxis and treatment strategies, improved diagnostic tests, and the introduction of new antifungal agents that may reduce morbidity and mortality caused by bIMI.

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来源期刊
Mycopathologia
Mycopathologia 生物-真菌学
CiteScore
6.80
自引率
3.60%
发文量
76
审稿时长
3 months
期刊介绍: Mycopathologia is an official journal of the International Union of Microbiological Societies (IUMS). Mycopathologia was founded in 1938 with the mission to ‘diffuse the understanding of fungal diseases in man and animals among mycologists’. Many of the milestones discoveries in the field of medical mycology have been communicated through the pages of this journal. Mycopathologia covers a diverse, interdisciplinary range of topics that is unique in breadth and depth. The journal publishes peer-reviewed, original articles highlighting important developments concerning medically important fungi and fungal diseases. The journal highlights important developments in fungal systematics and taxonomy, laboratory diagnosis of fungal infections, antifungal drugs, clinical presentation and treatment, and epidemiology of fungal diseases globally. Timely opinion articles, mini-reviews, and other communications are usually invited at the discretion of the editorial board. Unique case reports highlighting unprecedented progress in the diagnosis and treatment of fungal infections, are published in every issue of the journal. MycopathologiaIMAGE is another regular feature for a brief clinical report of potential interest to a mixed audience of physicians and laboratory scientists. MycopathologiaGENOME is designed for the rapid publication of new genomes of human and animal pathogenic fungi using a checklist-based, standardized format.
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