利尿苷抑制膀胱癌过程中肠道微生物群和代谢组学的变化

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-12-01 Epub Date: 2024-06-13 DOI:10.1080/10286020.2024.2366010

Zhao Zhai, Jie Fu, Meng-Liang Ye, Jing-Yue Wang, Hao-Jian Zhang, Hang Yu, Xin-Yu Yang, Hui Xu, Jia-Chun Hu, Jin-Yue Lu, Heng-Tong Zuo, Yi Zhao, Jian-Ye Song, Yong Zhang, Yan Wang, Nian-Zeng Xing

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引用次数: 0

摘要

鸢尾甙元是一种天然药物。然而，它对膀胱癌（BCa）的抑制作用及其潜在机制仍有待探索。研究发现，低剂量鸢尾素处理组和高浓度鸢尾素处理组的移植瘤比模型组的移植瘤小。利奎特甙元处理导致拉克氏菌、志贺氏菌、阿利斯蒂普斯菌和阿克曼斯菌发生变化。非靶向代谢组学分析表明，在模型组和高剂量利奎霉素处理组之间共发现了多种差异代谢物。这为liquiritigenin的抗肿瘤作用提供了新的方向和理论依据。

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The changes of intestinal microbiota and metabolomics during the inhibition of bladder cancer by liquiritigenin.

Liquiritigenin is a natural medicine. However, its inhibitory effect and its potential mechanism on bladder cancer (BCa) remain to be explored. It was found that it could be visualized that the transplanted tumours in the low-dose liquiritigenin -treated group and the high-dose liquiritigenin -treated group were smaller than those in the model group. Liquiritigenin treatment led to alterations in Lachnoclostridium, Escherichia-Shigella, Alistipes and Akkermansia. Non-targeted metabolomics analysis showed that a total of multiple differential metabolites were identified between the model group and the high-dose liquiritigenin-treated group. This provides a new direction and rationale for the antitumour effects of liquiritigenin.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.