系统分析非小细胞肺癌中的 IGF2BP 家族成员。

IF 3.8 3区 医学 Q2 GENETICS & HEREDITY
Liping Gong, Qin Liu, Ming Jia, Xifeng Sun
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引用次数: 0

摘要

背景:已知胰岛素样生长因子-2 mRNA结合蛋白1、2和3(IGF2BP1、IGF2BP2和IGF2BP3)参与了包括非小细胞肺癌(NSCLC)在内的多种人类癌症的肿瘤发生、转移、预后和癌症免疫。然而,有关非小细胞肺癌的文献大多忽略了肺鳞癌(LUSC)的具体情况,我们旨在解决这一疏忽:我们的研究评估了肿瘤和正常组织中 IGF2BP 家族成员的不同表达。我们进行了元分析,以评估 IGF2BPs 在肺腺癌(LUAD)和 LUSC 中的预后价值。此外,还研究了IGF2BPs与肿瘤免疫细胞浸润、突变特征、化疗敏感性和肿瘤突变负荷(TMB)之间的相关性。利用GSEA划分了与IGF2BPs相关的生物学过程和通路:结果:发现IGF2BP2和IGF2BP3在LUSC患者中表达上调。IGF2BP2 mRNA水平与LUSC和LUAD患者的癌症免疫相关。与LUSC相比,在LUAD的不同IGF2BP1/2/3表达组中观察到更高的基因突变频率。元分析显示,在LUAD患者中,总生存期(OS)与IGF2BP2/3表达呈显著负相关,而在LUSC患者中则不然。GSEA显示,在LUAD患者中,血管内皮生长因子与IGF2BP家族基因呈正相关,而在LUSC患者中,基质金属肽酶活性与IGF2BP家族基因呈反相关。在LUAD和LUSC中,一些化疗药物在IGF2BP高表达组中的IC50值明显较低:我们的研究结果表明,IGF2BPs 在 LUAD 和 LUSC 中发挥着不同的作用。结论:我们的研究结果表明,IGF2BPs 在 LUAD 和 LUSC 中发挥着不同的作用。这种差异突出表明,需要针对 LUAD 和 LUSC 独特的分子特征,制定量身定制的治疗策略和预后工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Systematic analysis of IGF2BP family members in non-small-cell lung cancer.

Background: The insulin-like growth factor-2 mRNA-binding proteins 1, 2, and 3 (IGF2BP1, IGF2BP2, and IGF2BP3) are known to be involved in tumorigenesis, metastasis, prognosis, and cancer immunity in various human cancers, including non-small cell lung cancer (NSCLC). However, the literature on NSCLC largely omits the specific context of lung squamous cell carcinoma (LUSC), an oversight we aim to address.

Methods: Our study evaluated the differential expression of IGF2BP family members in tumors and normal tissues. Meta-analyses were conducted to assess the prognostic value of IGF2BPs in lung adenocarcinoma (LUAD) and LUSC. Additionally, correlations between IGF2BPs and tumor immune cell infiltration, mutation characteristics, chemotherapy sensitivity, and tumor mutation burden (TMB) were investigated. GSEA was utilized to delineate biological processes and pathways associated with IGF2BPs.

Results: IGF2BP2 and IGF2BP3 expression were found to be upregulated in LUSC patients. IGF2BP2 mRNA levels were correlated with cancer immunity in both LUSC and LUAD patients. A higher frequency of gene mutations was observed in different IGF2BP1/2/3 expression groups in LUAD compared to LUSC. Meta-analyses revealed a significant negative correlation between overall survival (OS) and IGF2BP2/3 expression in LUAD patients but not in LUSC patients. GSEA indicated a positive association between VEGF and IGF2BP family genes in LUAD, while matrix metallopeptidase activity was inversely correlated with IGF2BP family genes in LUSC. Several chemotherapy drugs showed significantly lower IC50 values in high IGF2BP expression groups in both LUAD and LUSC.

Conclusion: Our findings indicated that IGF2BPs play different roles in LUAD and LUSC. This divergence highlights the need for tailored therapeutic strategies and prognostic tools, cognizant of the unique molecular profiles of LUAD and LUSC.

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来源期刊
Human Genomics
Human Genomics GENETICS & HEREDITY-
CiteScore
6.00
自引率
2.20%
发文量
55
审稿时长
11 weeks
期刊介绍: Human Genomics is a peer-reviewed, open access, online journal that focuses on the application of genomic analysis in all aspects of human health and disease, as well as genomic analysis of drug efficacy and safety, and comparative genomics. Topics covered by the journal include, but are not limited to: pharmacogenomics, genome-wide association studies, genome-wide sequencing, exome sequencing, next-generation deep-sequencing, functional genomics, epigenomics, translational genomics, expression profiling, proteomics, bioinformatics, animal models, statistical genetics, genetic epidemiology, human population genetics and comparative genomics.
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