PRDX6 对硒的高效利用可抑制铁毒性和铁变态反应

IF 12.5 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
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引用次数: 0

摘要

铁诱导铁变态筛选发现,PRDX6是一种硒蛋白合成因子。缺失 PRDX6 会大大降低硒蛋白 GPX4(铁变态反应的主要调节因子)的表达,并诱导铁变态反应。从机理上讲,PRDX6 通过充当硒输送蛋白提高了硒的利用效率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Efficient selenium use by PRDX6 suppresses iron toxicity and ferroptosis

Efficient selenium use by PRDX6 suppresses iron toxicity and ferroptosis

Efficient selenium use by PRDX6 suppresses iron toxicity and ferroptosis
An iron-induced ferroptosis screen revealed PRDX6 as a selenoprotein-synthesis factor. Loss of PRDX6 substantially decreased expression of the selenoprotein GPX4, a master regulator of ferroptosis, and induced ferroptosis. Mechanistically, PRDX6 increases the efficiency of selenium use by acting as a selenium delivery protein.
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来源期刊
Nature Structural & Molecular Biology
Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS
CiteScore
22.00
自引率
1.80%
发文量
160
审稿时长
3-8 weeks
期刊介绍: Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.
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