Liyun Wang , Miaomiao Ren , Cheng Chen , Xingyu Yang , Chenchen Zhang , Jing Gao , Jingwen Wang , Chunjun Yang
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Seven patients with different forms of HSDs, who had not responded well to conventional treatments, were enrolled in the study. These HSDs included cases of erythroplasia of Queyrat, pyoderma gangrenosum, keloids and hypertrophic scars, cellulitis, cutaneous lichen planus, and verruca vulgaris. Laser therapy was performed to remove the hyperplastic skin lesions, followed immediately by daily CAP treatment. The results were promising, with all patients successfully treated and no recurrence observed during the follow-up periods. The combined application of CAP and laser therapy proved to be an effective and complementary strategy for managing HSDs. 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引用次数: 0
摘要
现代医学认为,过度增生性皮肤病(HSDs)是一种复杂的综合征,以局部肥厚或增生以及炎症细胞浸润为特征。目前已提出了多种治疗方法,包括全身和局部药物疗法、激光干预、光动力疗法和手术,用于治疗增生性皮肤病。然而,激光治疗后的伤口愈合和复发等难题阻碍了激光治疗的有效性。为了克服这些挑战,我们开展了一项研究,将激光疗法与冷大气等离子体疗法(CAP)结合起来治疗 HSD。七名患有不同形式 HSD 的患者参加了这项研究,他们对常规治疗效果不佳。这些 HSD 包括奎拉特红斑、脓疱疮、瘢痕疙瘩和增生性疤痕、蜂窝组织炎、皮肤扁平苔藓和寻常疣。激光疗法可去除增生的皮肤病变,随后立即进行每日 CAP 治疗。结果很理想,所有患者都得到了成功治疗,而且在随访期间没有发现复发现象。事实证明,联合应用 CAP 和激光疗法是治疗增生性皮肤病的有效补充策略。这种创新方法为利用 CAP 促进伤口愈合和减轻炎症反应,从而解决激光疗法的局限性提供了证据。中国临床试验注册中心(ChiCTR2300069993)。
Cold atmospheric plasma in combination with laser therapy provides a window for the treatment of hyperproliferative skin disease
Modern medical understanding suggests that hyperproliferative skin diseases (HSDs) are complex syndromes characterized by localized hypertrophy or hyperplasia and infiltration of inflammatory cells. Various treatments, including systemic and topical pharmacotherapy, laser interventions, photodynamic therapy, and surgery, have been proposed for managing HSDs. However, challenges such as wound healing and recurrence after laser treatment have hindered the effectiveness of laser therapy. To overcome these challenges, we conducted a study combining laser therapy with cold atmospheric plasma (CAP) for the treatment of HSDs. Seven patients with different forms of HSDs, who had not responded well to conventional treatments, were enrolled in the study. These HSDs included cases of erythroplasia of Queyrat, pyoderma gangrenosum, keloids and hypertrophic scars, cellulitis, cutaneous lichen planus, and verruca vulgaris. Laser therapy was performed to remove the hyperplastic skin lesions, followed immediately by daily CAP treatment. The results were promising, with all patients successfully treated and no recurrence observed during the follow-up periods. The combined application of CAP and laser therapy proved to be an effective and complementary strategy for managing HSDs. This innovative approach provide evidence for addressing the limitation of laser therapy by utilizing CAP to promote wound healing and mitigate inflammatory responses.
Chinese Clinical Trial Registry (ChiCTR2300069993).
期刊介绍:
Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.