太空飞行环境对巨噬细胞系的影响

IF 4.4 1区 物理与天体物理 Q1 MULTIDISCIPLINARY SCIENCES
Rocky An, Virginia Katherine Blackwell, Bijan Harandi, Alicia C Gibbons, Olivia Siu, Iris Irby, Amy Rees, Nadjet Cornejal, Kristina M Sattler, Tao Sheng, Nicholas C Syracuse, David Loftus, Sergio R Santa Maria, Egle Cekanaviciute, Sigrid S Reinsch, Hami E Ray, Amber M Paul
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引用次数: 0

摘要

太空飞行和地面太空飞行类似物会改变免疫表型。巨噬细胞是重要的免疫细胞,是先天性免疫系统和适应性免疫系统的桥梁,并参与免疫调节的平衡过程。此外,巨噬细胞在启动免疫、抵御损伤和感染方面发挥着关键作用,还参与免疫清除和伤口愈合。巨噬细胞类型的异种群存在于许多组织中,并通过与其他生理系统(包括神经和内分泌系统)的直接或间接相互作用产生各种组织特异性效应。了解巨噬细胞如何对独特的太空环境做出反应至关重要,以便在未来的低地球轨道及更远的任务中采取适当的应对措施来保护乘员的安全。本综述重点介绍了目前有关巨噬细胞对太空飞行和太空飞行类似物的反应的文献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Influence of the spaceflight environment on macrophage lineages.

Spaceflight and terrestrial spaceflight analogs can alter immune phenotypes. Macrophages are important immune cells that bridge the innate and adaptive immune systems and participate in immunoregulatory processes of homeostasis. Furthermore, macrophages are critically involved in initiating immunity, defending against injury and infection, and are also involved in immune resolution and wound healing. Heterogeneous populations of macrophage-type cells reside in many tissues and cause a variety of tissue-specific effects through direct or indirect interactions with other physiological systems, including the nervous and endocrine systems. It is vital to understand how macrophages respond to the unique environment of space to safeguard crew members with appropriate countermeasures for future missions in low Earth orbit and beyond. This review highlights current literature on macrophage responses to spaceflight and spaceflight analogs.

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来源期刊
npj Microgravity
npj Microgravity Physics and Astronomy-Physics and Astronomy (miscellaneous)
CiteScore
7.30
自引率
7.80%
发文量
50
审稿时长
9 weeks
期刊介绍: A new open access, online-only, multidisciplinary research journal, npj Microgravity is dedicated to publishing the most important scientific advances in the life sciences, physical sciences, and engineering fields that are facilitated by spaceflight and analogue platforms.
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