日本鹌鹑胰腺胰外肽 YY 生成细胞和胰高血糖素免疫反应细胞中的淀粉样免疫反应。

IF 0.8 4区农林科学 Q4 ANATOMY & MORPHOLOGY

Anatomia Histologia Embryologia Pub Date : 2024-06-12 DOI:10.1111/ahe.13074

Bonten Yanagida, Toshiharu Yamamoto, Hirohumi Suzuki

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引用次数: 0

摘要

在这项研究中，我们使用特异性抗大鼠淀粉样蛋白血清研究了日本鹌鹑（Coturnix japonica）胰腺中淀粉样物质的分布。我们在胰腺胰岛外区域检测到了淀粉样蛋白免疫反应细胞，但在胰岛区域没有检测到。合成的含大鼠淀粉样蛋白的血清预吸收可消除染色特征。几乎所有淀粉免疫反应细胞都对肽 YY（PYY）呈免疫阳性。此外，某些淀粉免疫反应细胞的胰高血糖素染色也呈免疫阳性。胰岛外细胞共同分泌的淀粉样蛋白和PYY可能参与了胰腺的胰岛素和胰高血糖素释放调节，并通过中枢神经系统调节食物摄入量。

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Amylin-like immunoreactivity in the extra-islet peptide YY-producing and glucagon-immunoreactive cells in Japanese quail pancreas

In this study, we investigated amylin-like substance distribution in the pancreas of Japanese quail (Coturnix japonica) using a specific anti-rat amylin serum. We detected amylin-immunoreactive cells dispersed in the pancreatic extra-islet region but not in the islet region. The synthetic rat amylin-containing serum pre-absorption abolished the staining profile. Almost all amylin-immunoreactive cells were immuno-positive for peptide YY (PYY). In addition, certain amylin-immunoreactive cells stained immuno-positive for glucagon. Amylin and PYY co-secreted from the extra-islet cells might participate in the insulin and glucagon release regulation in the pancreas and food intake modulation through the central nervous system.

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来源期刊

Anatomia Histologia Embryologia ANATOMY & MORPHOLOGY-VETERINARY SCIENCES

CiteScore

1.90

自引率

11.10%

发文量

115

审稿时长

18-36 weeks

期刊介绍： Anatomia, Histologia, Embryologia is a premier international forum for the latest research on descriptive, applied and clinical anatomy, histology, embryology, and related fields. Special emphasis is placed on the links between animal morphology and veterinary and experimental medicine, consequently studies on clinically relevant species will be given priority. The editors welcome papers on medical imaging and anatomical techniques. The journal is of vital interest to clinicians, zoologists, obstetricians, and researchers working in biotechnology. Contributions include reviews, original research articles, short communications and book reviews.