对当前或缓解的重度抑郁症患者进行加速度测量得出的睡眠、体力活动和昼夜节律领域的综合建模。

IF 22.5 1区 医学 Q1 PSYCHIATRY
Sun Jung Kang, Andrew Leroux, Wei Guo, Debangan Dey, Marie-Pierre F Strippoli, Junrui Di, Julien Vaucher, Pedro Marques-Vidal, Peter Vollenweider, Martin Preisig, Kathleen R Merikangas, Vadim Zipunnikov
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引用次数: 0

摘要

重要性:加速度测量已越来越多地被用作情绪障碍患者睡眠、体力活动和昼夜节律的客观指标。然而,之前的大多数研究都只关注睡眠或体力活动,而没有考虑到睡眠或体力活动领域内部和跨领域之间的紧密联系;很少有研究对重度抑郁障碍(MDD)患者加速度测量领域的特质和状态特征进行区分:使用联合和个体差异解释法(JIVE)(一种新型多模态综合维度还原技术)识别加速度测量得出的睡眠、体力活动和昼夜节律等领域的联合和个体成分;研究联合和个体成分与当前和缓解的重度抑郁症之间的关联:这项横断面研究检查了瑞士洛桑人口队列研究第二波的数据。研究对象包括2317名成年人(其中1164人未患有多发性硬化症,185人患有目前的多发性硬化症,968人患有缓解的多发性硬化症),他们均接受过至少7天的加速度测量。统计分析于 2021 年 1 月至 2023 年 6 月进行:14天加速度测量得出的特征;当前和缓解的MDD。逻辑回归调整了年龄、性别、体重指数以及焦虑症和药物使用障碍:在参与研究的 2317 名成年人中,1261 人(54.42%)为女性,平均年龄(标清)为 61.79(9.97)岁。JIVE 将 28 个加速度测量特征简化为 3 个联合成分和 6 个单独成分(1 个睡眠成分、2 个体力活动成分、3 个昼夜节律成分)。联合成分分别解释了睡眠、体力活动和昼夜节律领域总变化的 58.5%、79.5% 和 54.5%。当前抑郁和缓解抑郁都与前两个联合成分有关,这两个联合成分分别与高强度体力活动的显著性、昼夜节律的振幅以及睡眠和体力活动的时间有关。MDD的昼夜节律性明显较弱:新型多模态维度还原技术的应用表明,体育锻炼、昼夜节律以及睡眠和体育锻炼的时间对 MDD 的共同影响非常重要;昼夜节律性减弱可能是 MDD 的特质标志。这项研究说明了加速度计作为抑郁症亚型的潜在生物标志物的价值,并强调了在未来研究中考虑整个 24 小时睡眠-觉醒周期的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Integrative Modeling of Accelerometry-Derived Sleep, Physical Activity, and Circadian Rhythm Domains With Current or Remitted Major Depression.

Importance: Accelerometry has been increasingly used as an objective index of sleep, physical activity, and circadian rhythms in people with mood disorders. However, most prior research has focused on sleep or physical activity alone without consideration of the strong within- and cross-domain intercorrelations; and few studies have distinguished between trait and state profiles of accelerometry domains in major depressive disorder (MDD).

Objectives: To identify joint and individual components of the domains derived from accelerometry, including sleep, physical activity, and circadian rhythmicity using the Joint and Individual Variation Explained method (JIVE), a novel multimodal integrative dimension-reduction technique; and to examine associations between joint and individual components with current and remitted MDD.

Design, setting, and participants: This cross-sectional study examined data from the second wave of a population cohort study from Lausanne, Switzerland. Participants included 2317 adults (1164 without MDD, 185 with current MDD, and 968 with remitted MDD) with accelerometry for at least 7 days. Statistical analysis was conducted from January 2021 to June 2023.

Main outcomes and measures: Features derived from accelerometry for 14 days; current and remitted MDD. Logistic regression adjusted for age, sex, body mass index, and anxiety and substance use disorders.

Results: Among 2317 adults included in the study, 1261 (54.42%) were female, and mean (SD) age was 61.79 (9.97) years. JIVE reduced 28 accelerometry features to 3 joint and 6 individual components (1 sleep, 2 physical activity, 3 circadian rhythms). Joint components explained 58.5%, 79.5%, 54.5% of the total variation in sleep, physical activity, and circadian rhythm domains, respectively. Both current and remitted depression were associated with the first 2 joint components that were distinguished by the salience of high-intensity physical activity and amplitude of circadian rhythm and timing of both sleep and physical activity, respectively. MDD had significantly weaker circadian rhythmicity.

Conclusions and relevance: Application of a novel multimodal dimension-reduction technique demonstrates the importance of joint influences of physical activity, circadian rhythms, and timing of both sleep and physical activity with MDD; dampened circadian rhythmicity may constitute a trait marker for MDD. This work illustrates the value of accelerometry as a potential biomarker for subtypes of depression and highlights the importance of consideration of the full 24-hour sleep-wake cycle in future studies.

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来源期刊
JAMA Psychiatry
JAMA Psychiatry PSYCHIATRY-
CiteScore
30.60
自引率
1.90%
发文量
233
期刊介绍: JAMA Psychiatry is a global, peer-reviewed journal catering to clinicians, scholars, and research scientists in psychiatry, mental health, behavioral science, and related fields. The Archives of Neurology & Psychiatry originated in 1919, splitting into two journals in 1959: Archives of Neurology and Archives of General Psychiatry. In 2013, these evolved into JAMA Neurology and JAMA Psychiatry, respectively. JAMA Psychiatry is affiliated with the JAMA Network, a group of peer-reviewed medical and specialty publications.
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