Fatima Daiana Dias Barroso, Lisandra Juvêncio da Silva, Helaine Almeida Queiroz, Lívia Gurgel do Amaral Valente Sá, Anderson Ramos da Silva, Cecília Rocha da Silva, João Batista de Andrade Neto, Bruno Coêlho Cavalcanti, Manoel Odorico de Moraes, Aurora Pinazo, Lourdes Pérez, Hélio Vitoriano Nobre Júnior
{"title":"与精氨酸复配的生物表面活性剂对耐甲氧西林金黄色葡萄球菌具有抗生物膜活性。","authors":"Fatima Daiana Dias Barroso, Lisandra Juvêncio da Silva, Helaine Almeida Queiroz, Lívia Gurgel do Amaral Valente Sá, Anderson Ramos da Silva, Cecília Rocha da Silva, João Batista de Andrade Neto, Bruno Coêlho Cavalcanti, Manoel Odorico de Moraes, Aurora Pinazo, Lourdes Pérez, Hélio Vitoriano Nobre Júnior","doi":"10.2217/fmb-2023-0271","DOIUrl":null,"url":null,"abstract":"<p><p><b>Aim:</b> The present study investigated the antimicrobial effectiveness of a rhamnolipid complexed with arginine (RLMIX_Arg) against planktonic cells and biofilms of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA). <b>Methodology:</b> Susceptibility testing was performed using the Clinical & Laboratory Standards Institute protocol: M07-A10, checkerboard test, biofilm in plates and catheters and flow cytometry were used. <b>Result:</b> RLMIX_Arg has bactericidal and synergistic activity with oxacillin. RLMIX_Arg inhibits the formation of MRSA biofilms on plates at sub-inhibitory concentrations and has antibiofilm action against MRSA in peripheral venous catheters. Catheters impregnated with RLMIX_Arg reduce the formation of MRSA biofilms. <b>Conclusion:</b> RLMIX_Arg exhibits potential for application in preventing infections related to methicillin-resistant <i>S. aureus</i> biofilms.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11259079/pdf/","citationCount":"0","resultStr":"{\"title\":\"Biosurfactant complexed with arginine has antibiofilm activity against methicillin-resistant <i>Staphylococcus aureus</i>.\",\"authors\":\"Fatima Daiana Dias Barroso, Lisandra Juvêncio da Silva, Helaine Almeida Queiroz, Lívia Gurgel do Amaral Valente Sá, Anderson Ramos da Silva, Cecília Rocha da Silva, João Batista de Andrade Neto, Bruno Coêlho Cavalcanti, Manoel Odorico de Moraes, Aurora Pinazo, Lourdes Pérez, Hélio Vitoriano Nobre Júnior\",\"doi\":\"10.2217/fmb-2023-0271\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Aim:</b> The present study investigated the antimicrobial effectiveness of a rhamnolipid complexed with arginine (RLMIX_Arg) against planktonic cells and biofilms of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA). <b>Methodology:</b> Susceptibility testing was performed using the Clinical & Laboratory Standards Institute protocol: M07-A10, checkerboard test, biofilm in plates and catheters and flow cytometry were used. <b>Result:</b> RLMIX_Arg has bactericidal and synergistic activity with oxacillin. RLMIX_Arg inhibits the formation of MRSA biofilms on plates at sub-inhibitory concentrations and has antibiofilm action against MRSA in peripheral venous catheters. Catheters impregnated with RLMIX_Arg reduce the formation of MRSA biofilms. <b>Conclusion:</b> RLMIX_Arg exhibits potential for application in preventing infections related to methicillin-resistant <i>S. aureus</i> biofilms.</p>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11259079/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.2217/fmb-2023-0271\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/6/12 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.2217/fmb-2023-0271","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/12 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Biosurfactant complexed with arginine has antibiofilm activity against methicillin-resistant Staphylococcus aureus.
Aim: The present study investigated the antimicrobial effectiveness of a rhamnolipid complexed with arginine (RLMIX_Arg) against planktonic cells and biofilms of methicillin-resistant Staphylococcus aureus (MRSA). Methodology: Susceptibility testing was performed using the Clinical & Laboratory Standards Institute protocol: M07-A10, checkerboard test, biofilm in plates and catheters and flow cytometry were used. Result: RLMIX_Arg has bactericidal and synergistic activity with oxacillin. RLMIX_Arg inhibits the formation of MRSA biofilms on plates at sub-inhibitory concentrations and has antibiofilm action against MRSA in peripheral venous catheters. Catheters impregnated with RLMIX_Arg reduce the formation of MRSA biofilms. Conclusion: RLMIX_Arg exhibits potential for application in preventing infections related to methicillin-resistant S. aureus biofilms.
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