对职业暴露于极低频磁场的工人进行暴露评估和细胞遗传学生物监测研究。

IF 1.8 3区 生物学 Q3 BIOLOGY
Ha Nguyen PhD, Giovani Vandewalle MD, Birgit Mertens PhD, Jean-Francois Collard PhD, Maurice Hinsenkamp MD, PhD, Luc Verschaeve PhD, Veronique Feipel PhD, Isabelle Magne PhD, Martine Souques PhD, Véronique Beauvois IR, Maryse Ledent MPE
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引用次数: 0

摘要

人类细胞遗传生物监测(HCB)长期以来一直用于评估工作环境对工人 DNA 完整性的潜在影响。然而,关于职业暴露于极低频电磁场(ELF-MFs)的遗传毒性影响的 HCB 研究受到暴露评估质量的限制。更具体地说,人们对暴露评估方法、暴露指标的选择以及暴露组的定义表示担忧。在这项研究中,考虑到工人连续三天的实际暴露量,采用彗星和细胞因子阻滞微核试验法,评估了职业暴露于 ELF-MFs 对 88 名电气行业工人外周血淋巴细胞的遗传毒性影响。界定暴露组别时采用了不同的方法。总体而言,汇总的 ELF-MF 数据表明,整个研究人群的暴露水平较低。这也表明,仅仅依靠职称可能会将 12 名工人错误地归入暴露组别。我们建议将个人暴露数据和工作职称的分层聚类相结合,以界定暴露组别。最终结果表明,职业中频暴露并不会明显诱发更多的遗传损伤。其他因素,如年龄或既往吸烟,而不是 ELF-MF 暴露,可能会影响细胞遗传学检测结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Exposure assessment and cytogenetic biomonitoring study of workers occupationally exposed to extremely low-frequency magnetic fields

Exposure assessment and cytogenetic biomonitoring study of workers occupationally exposed to extremely low-frequency magnetic fields

Human cytogenetic biomonitoring (HCB) has long been used to evaluate the potential effects of work environments on the DNA integrity of workers. However, HCB studies on the genotoxic effects of occupational exposure to extremely low-frequency electromagnetic fields (ELF-MFs) were limited by the quality of the exposure assessment. More specifically, concerns were raised regarding the method of exposure assessment, the selection of exposure metrics, and the definition of exposure group. In this study, genotoxic effects of occupational exposure to ELF-MFs were assessed on peripheral blood lymphocytes of 88 workers from the electrical sector using the comet and cytokinesis-block micronucleus assay, considering workers' actual exposure over three consecutive days. Different methods were applied to define exposure groups. Overall, the summarized ELF-MF data indicated a low exposure level in the whole study population. It also showed that relying solely on job titles might misclassify 12 workers into exposure groups. We proposed combining hierarchical agglomerative clustering on personal exposure data and job titles to define exposure groups. The final results showed that occupational MF exposure did not significantly induce more genetic damage. Other factors such as age or past smoking rather than ELF-MF exposure could affect the cytogenetic test outcomes.

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来源期刊
Bioelectromagnetics
Bioelectromagnetics 生物-生物物理
CiteScore
4.60
自引率
0.00%
发文量
44
审稿时长
6-12 weeks
期刊介绍: Bioelectromagnetics is published by Wiley-Liss, Inc., for the Bioelectromagnetics Society and is the official journal of the Bioelectromagnetics Society and the European Bioelectromagnetics Association. It is a peer-reviewed, internationally circulated scientific journal that specializes in reporting original data on biological effects and applications of electromagnetic fields that range in frequency from zero hertz (static fields) to the terahertz undulations and visible light. Both experimental and clinical data are of interest to the journal''s readers as are theoretical papers or reviews that offer novel insights into or criticism of contemporary concepts and theories of field-body interactions. The Bioelectromagnetics Society, which sponsors the journal, also welcomes experimental or clinical papers on the domains of sonic and ultrasonic radiation.
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