毕竟不是那么无用吞噬型小胶质细胞的可塑性

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2024-06-11 DOI:10.1016/j.immuni.2024.05.013

Aleksandra Deczkowska

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引用次数: 0

摘要

吞噬性小胶质细胞（如增殖区相关小胶质细胞和疾病相关小胶质细胞）在大脑发育过程中和各种脑部病变中短暂出现，但它们的功能和可塑性程度仍不清楚。在本期《免疫》杂志上，Barclay 等人建立了一种新型 Clec7a-CreERT2 小鼠系，以揭示这种细胞状态的可塑性及其在髓鞘损伤模型中的作用。

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Not so aDAMant after all: Plasticity of phagocytic microglia

Phagocytic microglia such as proliferative region-associated microglia and disease-associated microglia appear in the brain transiently during development and across various brain pathologies, but their function and degree of plasticity remain unclear. In this issue of Immunity, Barclay et al. established a novel Clec7a-CreER^T2 mouse line to uncover the plasticity of this cell state and its role in a model of myelin injury.

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.