用于表观遗传学研究的诱导近似标记和编辑技术

IF 6.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Chemical Biology Pub Date : 2024-06-20 DOI:10.1016/j.chembiol.2024.05.005

Chenwei Zhou , Sarah Wagner , Fu-Sen Liang

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引用次数: 0

摘要

表观遗传调控在各种生物和疾病过程中发挥着关键作用。目前有两条关键的研究路线，旨在揭示特定基因的内源性表观遗传事件（探测）和人为操纵表观遗传景观（编辑）。诱导接近的概念为表观遗传研究开发了强大的工具。诱导接近策略涉及将分子效应物与特定的基因组区域进行空间接近，以通过增加接近度实现对局部表观遗传环境的探测或操纵。在这篇综述中，我们将详细介绍诱导接近方法的发展及其在揭示错综复杂的表观遗传调控方面的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Induced proximity labeling and editing for epigenetic research

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Induced proximity labeling and editing for epigenetic research

Epigenetic regulation plays a pivotal role in various biological and disease processes. Two key lines of investigation have been pursued that aim to unravel endogenous epigenetic events at particular genes (probing) and artificially manipulate the epigenetic landscape (editing). The concept of induced proximity has inspired the development of powerful tools for epigenetic research. Induced proximity strategies involve bringing molecular effectors into spatial proximity with specific genomic regions to achieve the probing or manipulation of local epigenetic environments with increased proximity. In this review, we detail the development of induced proximity methods and applications in shedding light on the intricacies of epigenetic regulation.

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来源期刊

Cell Chemical Biology Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

14.70

自引率

2.30%

发文量

143

期刊介绍： Cell Chemical Biology, a Cell Press journal established in 1994 as Chemistry & Biology, focuses on publishing crucial advances in chemical biology research with broad appeal to our diverse community, spanning basic scientists to clinicians. Pioneering investigations at the chemistry-biology interface, the journal fosters collaboration between these disciplines. We encourage submissions providing significant conceptual advancements of broad interest across chemical, biological, clinical, and related fields. Particularly sought are articles utilizing chemical tools to perturb, visualize, and measure biological systems, offering unique insights into molecular mechanisms, disease biology, and therapeutics.