Yiqi Yang , Kai Huang , Kai Yuan , Yihao Liu , Yixuan Lin , Lingyan Cao , Guangzheng Yang , Yihe Hu , Pengfei Lei , Shuai Li , Jiale Jin , Xihui Gao , Wenxuan Shi , Tingting Tang , Shengbing Yang
{"title":"一种新型抗菌免疫激活剂:Bi-MOF 作为 H2S 清除剂可抑制 HIF-1α S-硫酸化并减轻植入物相关感染","authors":"Yiqi Yang , Kai Huang , Kai Yuan , Yihao Liu , Yixuan Lin , Lingyan Cao , Guangzheng Yang , Yihe Hu , Pengfei Lei , Shuai Li , Jiale Jin , Xihui Gao , Wenxuan Shi , Tingting Tang , Shengbing Yang","doi":"10.1016/j.nantod.2024.102334","DOIUrl":null,"url":null,"abstract":"<div><p>Implant-associated infection (IAI) has significantly impeded the progress of surgery, and a properly functioning antibacterial immune response is critical for preventing persistent infection and reinfection. However, the efficacy of current infection immunotherapy remains considerably suboptimal, primarily because of the lack of validated therapeutic targets and interventions. Herein, we identify a bismuth-based metal organic frameworks (Bi-MOF) as an efficient intracellular hydrogen sulfide (H<sub>2</sub>S) scavenger that promotes the antibacterial response of macrophages through the inhibition of hypoxia inducible factor-1α (HIF-1α) S-sulfhydration and subsequent ubiquitin-dependent degradation. The reduction in H<sub>2</sub>S levels by Bi-MOF <em>in vivo</em> contributes to accelerated the clearance of bacteria, prevention of bone destruction, and augmentation of innate immunity in a mouse IAI model. Moreover, Bi-MOF also boost bacteria-specific adaptive immunity, thereby generating long-lasting protection against reinfection. Together, our results demonstrate that H<sub>2</sub>S-responsive Bi-MOF offer a promising immunotherapeutic approach as a potential alternative to antibiotics for managing stubborn IAIs.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":null,"pages":null},"PeriodicalIF":13.2000,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A novel antibacterial immune activator: Bi-MOF acts as H2S scavenger to suppress HIF-1α S-sulfhydration and alleviate implant-associated infection\",\"authors\":\"Yiqi Yang , Kai Huang , Kai Yuan , Yihao Liu , Yixuan Lin , Lingyan Cao , Guangzheng Yang , Yihe Hu , Pengfei Lei , Shuai Li , Jiale Jin , Xihui Gao , Wenxuan Shi , Tingting Tang , Shengbing Yang\",\"doi\":\"10.1016/j.nantod.2024.102334\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Implant-associated infection (IAI) has significantly impeded the progress of surgery, and a properly functioning antibacterial immune response is critical for preventing persistent infection and reinfection. However, the efficacy of current infection immunotherapy remains considerably suboptimal, primarily because of the lack of validated therapeutic targets and interventions. Herein, we identify a bismuth-based metal organic frameworks (Bi-MOF) as an efficient intracellular hydrogen sulfide (H<sub>2</sub>S) scavenger that promotes the antibacterial response of macrophages through the inhibition of hypoxia inducible factor-1α (HIF-1α) S-sulfhydration and subsequent ubiquitin-dependent degradation. The reduction in H<sub>2</sub>S levels by Bi-MOF <em>in vivo</em> contributes to accelerated the clearance of bacteria, prevention of bone destruction, and augmentation of innate immunity in a mouse IAI model. Moreover, Bi-MOF also boost bacteria-specific adaptive immunity, thereby generating long-lasting protection against reinfection. Together, our results demonstrate that H<sub>2</sub>S-responsive Bi-MOF offer a promising immunotherapeutic approach as a potential alternative to antibiotics for managing stubborn IAIs.</p></div>\",\"PeriodicalId\":395,\"journal\":{\"name\":\"Nano Today\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":13.2000,\"publicationDate\":\"2024-06-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nano Today\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1748013224001890\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano Today","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1748013224001890","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
A novel antibacterial immune activator: Bi-MOF acts as H2S scavenger to suppress HIF-1α S-sulfhydration and alleviate implant-associated infection
Implant-associated infection (IAI) has significantly impeded the progress of surgery, and a properly functioning antibacterial immune response is critical for preventing persistent infection and reinfection. However, the efficacy of current infection immunotherapy remains considerably suboptimal, primarily because of the lack of validated therapeutic targets and interventions. Herein, we identify a bismuth-based metal organic frameworks (Bi-MOF) as an efficient intracellular hydrogen sulfide (H2S) scavenger that promotes the antibacterial response of macrophages through the inhibition of hypoxia inducible factor-1α (HIF-1α) S-sulfhydration and subsequent ubiquitin-dependent degradation. The reduction in H2S levels by Bi-MOF in vivo contributes to accelerated the clearance of bacteria, prevention of bone destruction, and augmentation of innate immunity in a mouse IAI model. Moreover, Bi-MOF also boost bacteria-specific adaptive immunity, thereby generating long-lasting protection against reinfection. Together, our results demonstrate that H2S-responsive Bi-MOF offer a promising immunotherapeutic approach as a potential alternative to antibiotics for managing stubborn IAIs.
期刊介绍:
Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.