基于喹唑啉的 HDAC 抑制剂作为抗癌药物的深入研究。

IF 3.3 3区医学 Q2 CHEMISTRY, MEDICINAL

Mini reviews in medicinal chemistry Pub Date : 2024-01-01 DOI:10.2174/0113895575303614240527093106

Elena Martino, Shruti Thakur, Arun Kumar, Ashok Kumar Yadav, Donatella Boschi, Deepak Kumar, Marco Lolli

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引用次数: 0

摘要

癌症仍然是全球死亡的主要原因，而有效的治疗方法仍然有限。虽然化疗显著提高了生存率，但也带来了许多副作用。因此，开发毒性极低的强效抗癌药物一直是个挑战。喹唑啉分子的多功能性使其成为开发各种抗肿瘤药物的关键成分，在创新癌症疗法中大有可为。这篇简明综述旨在揭示喹唑啉类化合物在开发以组蛋白去乙酰化酶（HDAC）为靶点的抗癌药物方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Insight in Quinazoline-based HDAC Inhibitors as Anti-cancer Agents.

Cancer remains a primary cause of death globally, and effective treatments are still limited. While chemotherapy has notably enhanced survival rates, it brings about numerous side effects. Consequently, the ongoing challenge persists in developing potent anti-cancer agents with minimal toxicity. The versatile nature of the quinazoline moiety has positioned it as a pivotal component in the development of various antitumor agents, showcasing its promising role in innovative cancer therapeutics. This concise review aims to reveal the potential of quinazolines in creating anticancer medications that target histone deacetylases (HDACs).

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来源期刊

Mini reviews in medicinal chemistry 医学-医药化学

CiteScore

7.80

自引率

0.00%

发文量

231

审稿时长

6 months

期刊介绍： The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines. Mini-Reviews in Medicinal Chemistry covers all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.